TIFA

Gene Name		TRAF-interacting protein with forkhead-associated domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component
	Molecular Function	Protein Binding
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		16 interactors: AP1M1 ARHGEF39 DVL2 IRAK1 LNX1 NIF3L1 NUDT18 NXF1 RPL9 SDCBP SDCBP2 TIFAB TNFAIP8 TRAF2 TRAF6 TXN2
Entrez ID		92610
HPRD ID		09835
Ensembl ID
Uniprot IDs		Q96CG3
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JUN Kinase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Immunoglobulin Secretion Regulation Of MAPK Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Positive Regulation Of T Cell Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of T Cell Cytokine Production Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Involved In Immune Response Protein Modification By Small Protein Conjugation Regulation Of Innate Immune Response Response To External Stimulus Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway
Tagcloud ?		activate activates catalyzing conjugating consisting crude cytosolic defective exists forkhead ikk interesting ligase lys oligomeric oligomerization oligomers polyubiquitin polyubiquitination really reconstitution t2bp tak1 traf traf6 transforming ub ubc13 uev1a