TIFA and GSDME

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIFA	GSDME
Description		TRAF interacting protein with forkhead associated domain	gasdermin E
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Cardiolipin Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Homooligomerization	Positive Regulation Of Immune Response To Tumor Cell Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Programmed Cell Death Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of MAPK Cascade Transmembrane Transport Pyroptotic Inflammatory Response Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway	Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs
Diseases			Deafness, autosomal dominant
GWAS		Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		25 interacting genes: ALPK1 AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP3 TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2	5 interacting genes: CFTR ITGB1BP1 PTN TIFA WEE2-AS1
Entrez ID		92610	1687
HPRD ID		09835	02996
Ensembl ID		ENSG00000145365	ENSG00000105928
Uniprot IDs		Q96CG3	A4FVA8 O60443
PDB IDs		4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Identical Protein Binding Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Interleukin-33-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Interleukin-2 Production CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Binding Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Death Programmed Cell Death Immune Response-regulating Signaling Pathway Intracellular Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Positive Regulation Of Immune System Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Cellular Response To Forskolin Response To Forskolin
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