TIFA and AP1M1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		TIFA	AP1M1
Gene Name		TRAF-interacting protein with forkhead-associated domain	adaptor-related protein complex 1, mu 1 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Golgi Membrane Lysosomal Membrane Cytosol Membrane Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways			Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: AP1M1 ARHGEF39 DVL2 IRAK1 LNX1 NIF3L1 NUDT18 NXF1 RPL9 SDCBP SDCBP2 TIFAB TNFAIP8 TRAF2 TRAF6 TXN2	43 interactors: AP1B1 AP1M2 AP2B1 BRCA1 CEP57L1 CORO7 CTLA4 DCX DVL2 DZIP3 EHD2 ETV6 FAM9B FXR2 GAK GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KRT40 KRTAP10-3 KRTAP10-7 LAMP1 LDOC1 LZTS2 MTF1 PHC2 PIGR PNMA5 RUNDC3A SDCCAG3 SELP SSX2IP TGOLN2 TIFA TNIP1 VAMP4 ZBTB14 ZBTB43 ZBTB44 ZBTB8A
Entrez ID		92610	8907
HPRD ID		09835	04639
Ensembl ID			ENSG00000072958
Uniprot IDs		Q96CG3	B3KNH5 E7ENJ6 Q59EK3 Q9BXS5
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JUN Kinase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Immunoglobulin Secretion Regulation Of MAPK Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Positive Regulation Of T Cell Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of T Cell Cytokine Production Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Involved In Immune Response Protein Modification By Small Protein Conjugation Regulation Of Innate Immune Response Response To External Stimulus Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway	Vesicle-mediated Transport Cellular Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Defense Response To Virus By Virus Intracellular Transport Endosomal Transport Protein Localization Lysosomal Transport Golgi Vesicle Transport Regulation Of Immune System Process Cellular Protein Localization Vacuolar Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Microtubule Cytoskeleton Organization Endomembrane System Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Transport Regulation Of Cellular Process Startle Response Microtubule-based Process Endosome To Lysosome Transport Positive Regulation Of Cell Activation Cytoskeleton Organization Clathrin-mediated Endocytosis Establishment Of Protein Localization Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Histone H4-K16 Acetylation Membrane Organization Cellular Protein Complex Assembly Organelle Organization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Intrahepatic Bile Duct Development Positive Regulation Of Natural Killer Cell Degranulation Selenium Compound Metabolic Process Cytoplasmic Transport Glutamate Receptor Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Golgi To Lysosome Transport Neuron-neuron Synaptic Transmission
Tagcloud ?		activate activates catalyzing conjugating consisting crude cytosolic defective exists forkhead ikk interesting ligase lys oligomeric oligomerization oligomers polyubiquitin polyubiquitination really reconstitution t2bp tak1 traf traf6 transforming ub ubc13 uev1a	19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic
Tagcloud (Difference) ?		activate activates catalyzing conjugating consisting crude cytosolic defective exists forkhead ikk interesting ligase lys oligomeric oligomerization oligomers polyubiquitin polyubiquitination really reconstitution t2bp tak1 traf traf6 transforming ub ubc13 uev1a	19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic
Tagcloud (Intersection) ?