TIFA and TXN2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TIFA	TXN2
Description		TRAF interacting protein with forkhead associated domain	thioredoxin 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Homooligomerization	Cell Redox Homeostasis
Pathways		TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway	Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		25 interacting genes: ALPK1 AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP3 TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2	78 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B CSTPP1 DCTD DDIT3 ETHE1 FAM9B FHL5 GOLGA6L9 GPRASP2 GPRASP3 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32
Entrez ID		92610	25828
HPRD ID		09835	07161
Ensembl ID		ENSG00000145365	ENSG00000100348
Uniprot IDs		Q96CG3	Q99757
PDB IDs		4YM4 4ZGI 5ZUJ 6A33	1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Identical Protein Binding Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Interleukin-33-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Interleukin-2 Production CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Binding Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Death Programmed Cell Death Immune Response-regulating Signaling Pathway Intracellular Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Positive Regulation Of Immune System Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Identical Protein Binding Protein Binding Microtubule Organizing Center Organelle Organization Cytoskeleton Organization Cytoskeleton Membraneless Organelle Assembly Spindle Assembly Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Synaptonemal Complex Microtubule Cytoskeleton Organization Cytoplasm Microtubule-based Process
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