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UBE2L6 and LONRF1
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid, two hybrid)
UBE2L6
LONRF1
Gene Name
ubiquitin-conjugating enzyme E2L 6
LON peptidase N-terminal domain and ring finger 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
ISG15 Transferase Activity
ATP-dependent Peptidase Activity
Zinc Ion Binding
Biological Process
Cellular Protein Modification Process
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
ISG15-protein Conjugation
Negative Regulation Of Type I Interferon Production
Innate Immune Response
Proteolysis
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
Cytokine Signaling in Immune system
Class I MHC mediated antigen processing & presentation
Antiviral mechanism by IFN-stimulated genes
Adaptive Immune System
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
ARHGDIA
ARIH1
ARIH2
CBLC
DTX3
FLT3
LONRF1
MAP3K1
MUL1
PARK2
PJA2
RAD23A
RBCK1
RBX1
RNF122
RNF125
RNF144A
RNF144B
RNF150
RNF19A
RNF216
RNF25
RNF4
RNF40
RUNX1
SIAH1
SIAH2
SPEN
TOPORS
TRAF7
TRIM25
TRIM27
TRIM8
UBA6
UBA7
UBC
UBE3A
32 interactors:
ADAMTSL4
ALAS1
ATG9A
BRCA1
BYSL
CALCOCO2
CCDC36
CRX
EFHC2
GORASP1
GORASP2
IKZF2
IQCF2
KAT5
KCTD9
KRT31
KRTAP13-1
LHX4
NR4A1
PLSCR1
RBPMS
SFN
SPRY2
STAU1
STX11
TRIM42
TRIM9
UBE2L6
UCHL3
USP2
WDYHV1
XIAP
Entrez ID
9246
91694
HPRD ID
04867
08674
Ensembl ID
ENSG00000156587
ENSG00000154359
Uniprot IDs
O14933
Q17RB8
PDB IDs
1WZV
1WZW
2KJH
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Polyubiquitination
Catabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Metabolic Process
Protein K63-linked Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Signaling
Protein Monoubiquitination
Regulation Of Type I Interferon Production
Negative Regulation Of Cytokine Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Viral Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Signal Transduction
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Stimulus
Regulation Of Viral Release From Host Cell
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Organic Substance
Apoptotic Process
Response To Stimulus
Programmed Cell Death
Regulation Of Cytokine Production
Regulation Of Protein Ubiquitination
Regulation Of Cellular Protein Metabolic Process
Cell Death
Regulation Of Kinase Activity
Death
Cellular Response To Cytokine Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
DNA Damage Response, Signal Transduction Resulting In Transcription
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Modification-dependent Protein Catabolic Process
Positive Regulation Of Protein Acetylation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Protein Catabolic Process
Apoptotic Process
Negative Regulation Of Cell Death
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Apoptotic Process
Cell Death
Death
Negative Regulation Of Hydrolase Activity
Androgen Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Gene Expression
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Death
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Positive Regulation Of Photoreceptor Cell Differentiation
Positive Regulation Of Cellular Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Innate Immune Response
Negative Regulation Of Cellular Protein Metabolic Process
Synaptic Vesicle Exocytosis
Regulation Of Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Medial Motor Column Neuron Differentiation
Positive Regulation Of Histone H3-K9 Acetylation
Negative Regulation Of SNARE Complex Assembly
Positive Regulation Of Protein Linear Polyubiquitination
Late Nucleophagy
Piecemeal Microautophagy Of Nucleus
Negative Regulation Of Protein Metabolic Process
Response To Stress
Positive Regulation Of Transcription, DNA-templated
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Viral Genome Replication
Tagcloud
?
btbr
c57blks
db
dba
diabesity
dissection
hlbomdife
hllt
hyperglycaemia
ifi202b
inbred
introgression
jngj
lean
lep
lepr
lisch
nzo
ob
obesity
outcross
pctp
positional
sorcs1
tallyho
tbc1d1
tomosyn
zealand
zfp69
Tagcloud (Difference)
?
btbr
c57blks
db
dba
diabesity
dissection
hlbomdife
hllt
hyperglycaemia
ifi202b
inbred
introgression
jngj
lean
lep
lepr
lisch
nzo
ob
obesity
outcross
pctp
positional
sorcs1
tallyho
tbc1d1
tomosyn
zealand
zfp69
Tagcloud (Intersection)
?