UBE2L6 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 10558980)
0

Data Source:
HPRD (two hybrid, in vitro)

		UBE2L6	UBE3A
Description		ubiquitin conjugating enzyme E2 L6	ubiquitin protein ligase E3A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Protein Modification By Small Protein Conjugation Protein Modification Process Innate Immune Response	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS			Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		44 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 ITCH LONRF1 MAP3K1 MID1 MUL1 NEDD4 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM13 TRIM25 TRIM27 TRIM28 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A YAP1	165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446
Entrez ID		9246	7337
HPRD ID		04867	03375
Ensembl ID		ENSG00000156587	ENSG00000114062
Uniprot IDs		O14933	A0A6Q8PHE5 Q05086 Q9H2G0
PDB IDs		1WZV 1WZW 2KJH 8OIF 8SE9 8SEA 8SEB 8SV8	1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Transferase Activity Proteolysis Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Monoubiquitination Suppression Of Viral Release By Host Protein K63-linked Ubiquitination Protein Autoubiquitination Transcription Coactivator Activity Innate Immune Response Negative Regulation Of Viral Transcription Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Viral Transcription SUMO Transferase Activity Cytoplasm Defense Response To Symbiont Defense Response To Other Organism Protein K6-linked Ubiquitination Defense Response To Virus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Negative Regulation Of Viral Process Regulation Of Viral Process Ubiquitin-like Modifier Activating Enzyme Activity Response To Other Organism Protein K29-linked Ubiquitination Positive Regulation Of Cell Communication	Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription
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