UBE2L6 and TRIM13

Number of citations of the paper that reports this interaction (PubMedID 37205848)
54

Data Source:
BioGRID (pull down)

		UBE2L6	TRIM13
Description		ubiquitin conjugating enzyme E2 L6	tripartite motif containing 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Endoplasmic Reticulum
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Protein Modification By Small Protein Conjugation Protein Modification Process Innate Immune Response	Immune System Process Positive Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Viral Transcription ERAD Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	ER Quality Control Compartment (ERQC)
Drugs			Etorphine Diprenorphine Dihydromorphine
Diseases
GWAS			Diastolic blood pressure ( 30224653) Height ( 23563607) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		44 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 ITCH LONRF1 MAP3K1 MID1 MUL1 NEDD4 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM13 TRIM25 TRIM27 TRIM28 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A YAP1	16 interacting genes: AKT1 ARHGDIA CCNA1 CDC34 GMCL1 MDM2 ROBO2 UBE2C UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N
Entrez ID		9246	10206
HPRD ID		04867	10414
Ensembl ID		ENSG00000156587	ENSG00000204977
Uniprot IDs		O14933	O60858
PDB IDs		1WZV 1WZW 2KJH 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Transferase Activity Proteolysis Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Monoubiquitination Suppression Of Viral Release By Host Protein K63-linked Ubiquitination Protein Autoubiquitination Transcription Coactivator Activity Innate Immune Response Negative Regulation Of Viral Transcription Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Viral Transcription SUMO Transferase Activity Cytoplasm Defense Response To Symbiont Defense Response To Other Organism Protein K6-linked Ubiquitination Defense Response To Virus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Negative Regulation Of Viral Process Regulation Of Viral Process Ubiquitin-like Modifier Activating Enzyme Activity Response To Other Organism Protein K29-linked Ubiquitination Positive Regulation Of Cell Communication	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ATP Binding Proteasomal Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex Nucleus ISG15 Transferase Activity Cytosol ISG15-protein Conjugation Cell Cycle Phase Transition Free Ubiquitin Chain Polymerization Protein Monoubiquitination Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activator Activity Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin Binding Nucleoplasm Positive Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Phase Transition Response To Ether Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Cell Cycle Cellular Response To Hormone Stimulus Regulation Of Protein Modification Process Negative Regulation Of Protein Maturation
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