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UBE2L6 and RNF25
Number of citations of the paper that reports this interaction (PMID
19690564
)
33
Data Source:
BioGRID
(two hybrid)
UBE2L6
RNF25
Gene Name
ubiquitin-conjugating enzyme E2L 6
ring finger protein 25
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
ISG15 Transferase Activity
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
NF-kappaB Binding
Biological Process
Cellular Protein Modification Process
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
ISG15-protein Conjugation
Negative Regulation Of Type I Interferon Production
Innate Immune Response
Protein Ubiquitination
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
Cytokine Signaling in Immune system
Class I MHC mediated antigen processing & presentation
Antiviral mechanism by IFN-stimulated genes
Adaptive Immune System
Innate Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
ARHGDIA
ARIH1
ARIH2
CBLC
DTX3
FLT3
LONRF1
MAP3K1
MUL1
PARK2
PJA2
RAD23A
RBCK1
RBX1
RNF122
RNF125
RNF144A
RNF144B
RNF150
RNF19A
RNF216
RNF25
RNF4
RNF40
RUNX1
SIAH1
SIAH2
SPEN
TOPORS
TRAF7
TRIM25
TRIM27
TRIM8
UBA6
UBA7
UBC
UBE3A
11 interactors:
RELA
TRIM27
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L6
UBE2U
Entrez ID
9246
64320
HPRD ID
04867
09737
Ensembl ID
ENSG00000156587
ENSG00000163481
Uniprot IDs
O14933
Q96BH1
PDB IDs
1WZV
1WZW
2KJH
2DAY
2DMF
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Polyubiquitination
Catabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Metabolic Process
Protein K63-linked Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Signaling
Protein Monoubiquitination
Regulation Of Type I Interferon Production
Negative Regulation Of Cytokine Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Viral Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Signal Transduction
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Stimulus
Regulation Of Viral Release From Host Cell
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Organic Substance
Apoptotic Process
Response To Stimulus
Programmed Cell Death
Regulation Of Cytokine Production
Regulation Of Protein Ubiquitination
Regulation Of Cellular Protein Metabolic Process
Cell Death
Regulation Of Kinase Activity
Death
Cellular Response To Cytokine Stimulus
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K11-linked Ubiquitination
Protein K63-linked Ubiquitination
ISG15-protein Conjugation
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Protein Modification Process
Toll-like Receptor 4 Signaling Pathway
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Cellular Protein Metabolic Process
Innate Immune Response
Cellular Macromolecule Catabolic Process
Positive Regulation Of Innate Immune Response
Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Regulation Of DNA-templated Transcription In Response To Stress
Regulation Of Innate Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Immune Response
Defense Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Regulation Of Type I Interferon Production
Cellular Response To Oxygen Levels
Negative Regulation Of Protein Catabolic Process
Response To Stress
Cellular Response To Stress
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Catabolic Process
Regulation Of Cytokine Production
Cellular Metabolic Process
Negative Regulation Of Cytokine Production
Mitotic Spindle Assembly Checkpoint
Histone Ubiquitination
Tagcloud
?
btbr
c57blks
db
dba
diabesity
dissection
hlbomdife
hllt
hyperglycaemia
ifi202b
inbred
introgression
jngj
lean
lep
lepr
lisch
nzo
ob
obesity
outcross
pctp
positional
sorcs1
tallyho
tbc1d1
tomosyn
zealand
zfp69
Tagcloud (Difference)
?
btbr
c57blks
db
dba
diabesity
dissection
hlbomdife
hllt
hyperglycaemia
ifi202b
inbred
introgression
jngj
lean
lep
lepr
lisch
nzo
ob
obesity
outcross
pctp
positional
sorcs1
tallyho
tbc1d1
tomosyn
zealand
zfp69
Tagcloud (Intersection)
?