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UBE2L6 and DTX3
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
UBE2L6
DTX3
Gene Name
ubiquitin-conjugating enzyme E2L 6
deltex 3, E3 ubiquitin ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
ISG15 Transferase Activity
Zinc Ion Binding
Ligase Activity
Biological Process
Cellular Protein Modification Process
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
ISG15-protein Conjugation
Negative Regulation Of Type I Interferon Production
Innate Immune Response
Notch Signaling Pathway
Protein Ubiquitination
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
Cytokine Signaling in Immune system
Class I MHC mediated antigen processing & presentation
Antiviral mechanism by IFN-stimulated genes
Adaptive Immune System
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
37 interactors:
ARHGDIA
ARIH1
ARIH2
CBLC
DTX3
FLT3
LONRF1
MAP3K1
MUL1
PARK2
PJA2
RAD23A
RBCK1
RBX1
RNF122
RNF125
RNF144A
RNF144B
RNF150
RNF19A
RNF216
RNF25
RNF4
RNF40
RUNX1
SIAH1
SIAH2
SPEN
TOPORS
TRAF7
TRIM25
TRIM27
TRIM8
UBA6
UBA7
UBC
UBE3A
25 interactors:
DTX1
DTX2
RNF141
RNF38
TRAF4
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2DNL
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2K
UBE2L3
UBE2L6
UBE2V1
UBE2W
UEVLD
USP1
USP2
USP21
XIAP
ZDHHC17
Entrez ID
9246
196403
HPRD ID
04867
16842
Ensembl ID
ENSG00000156587
ENSG00000178498
Uniprot IDs
O14933
Q8N9I9
PDB IDs
1WZV
1WZW
2KJH
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Polyubiquitination
Catabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Metabolic Process
Protein K63-linked Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Signaling
Protein Monoubiquitination
Regulation Of Type I Interferon Production
Negative Regulation Of Cytokine Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Viral Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Signal Transduction
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Stimulus
Regulation Of Viral Release From Host Cell
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Organic Substance
Apoptotic Process
Response To Stimulus
Programmed Cell Death
Regulation Of Cytokine Production
Regulation Of Protein Ubiquitination
Regulation Of Cellular Protein Metabolic Process
Cell Death
Regulation Of Kinase Activity
Death
Cellular Response To Cytokine Stimulus
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein K11-linked Ubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Proteolysis
ISG15-protein Conjugation
Protein K63-linked Ubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Metabolic Process
Regulation Of Proteolysis
Regulation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Cellular Response To Stress
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein Monoubiquitination
Activation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To DNA Damage Stimulus
Tagcloud
?
btbr
c57blks
db
dba
diabesity
dissection
hlbomdife
hllt
hyperglycaemia
ifi202b
inbred
introgression
jngj
lean
lep
lepr
lisch
nzo
ob
obesity
outcross
pctp
positional
sorcs1
tallyho
tbc1d1
tomosyn
zealand
zfp69
Tagcloud (Difference)
?
btbr
c57blks
db
dba
diabesity
dissection
hlbomdife
hllt
hyperglycaemia
ifi202b
inbred
introgression
jngj
lean
lep
lepr
lisch
nzo
ob
obesity
outcross
pctp
positional
sorcs1
tallyho
tbc1d1
tomosyn
zealand
zfp69
Tagcloud (Intersection)
?