UBE2L6 and RNF122

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2L6	RNF122
Description		ubiquitin conjugating enzyme E2 L6	ring finger protein 122
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-like Protein Transferase Activity ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Protein Modification By Small Protein Conjugation Protein Modification Process Innate Immune Response	Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS			Pulse pressure ( 30578418)
Interacting Genes		44 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 ITCH LONRF1 MAP3K1 MID1 MUL1 NEDD4 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM13 TRIM25 TRIM27 TRIM28 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A YAP1	12 interacting genes: AQP1 CDS2 CTSA GPR37L1 PLLP RIGI UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L6 UBE2N
Entrez ID		9246	79845
HPRD ID		04867	11498
Ensembl ID		ENSG00000156587	ENSG00000133874
Uniprot IDs		O14933	Q9H9V4
PDB IDs		1WZV 1WZW 2KJH 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Transferase Activity Proteolysis Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Monoubiquitination Suppression Of Viral Release By Host Protein K63-linked Ubiquitination Protein Autoubiquitination Transcription Coactivator Activity Innate Immune Response Negative Regulation Of Viral Transcription Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Viral Transcription SUMO Transferase Activity Cytoplasm Defense Response To Symbiont Defense Response To Other Organism Protein K6-linked Ubiquitination Defense Response To Virus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Negative Regulation Of Viral Process Regulation Of Viral Process Ubiquitin-like Modifier Activating Enzyme Activity Response To Other Organism Protein K29-linked Ubiquitination Positive Regulation Of Cell Communication	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation ISG15 Transferase Activity Proteolysis Protein Monoubiquitination ISG15-protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Transferase Activity Positive Regulation Of Protein Polyubiquitination ATP Binding Regulation Of Protein Polyubiquitination Protein Modification Process Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Nucleotide Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Catabolic Process Protein Autoubiquitination Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Lumenal Side Of Lysosomal Membrane Antiviral Innate Immune Response Phosphatidate Cytidylyltransferase Activity Prosaposin Receptor Activity Regulation Of Transcytosis Protein Metabolic Process TOR Signaling Ubiquitin Protein Ligase Activity Negative Regulation Of TOR Signaling Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of TORC1 Signaling UBC13-MMS2 Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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