CHMP4C and USP8

Number of citations of the paper that reports this interaction (PMID 17711858)
40

Data Source:
BioGRID (pull down, pull down)

		CHMP4C	USP8
Gene Name		charged multivesicular body protein 4C	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Cytosol Midbody Late Endosome Membrane Extracellular Vesicular Exosome Flemming Body	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Abscission Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Negative Regulation Of Cytokinesis Regulation Of Viral Process Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)
Protein-Protein Interactions		10 interactors: CC2D1A CHMP4A CHMP4B HMGB3P1 PDCD6IP STAMBP TRPC4AP USP54 USP8 VPS4A	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		92421	9101
HPRD ID		18135	04405
Ensembl ID		ENSG00000164695	ENSG00000138592
Uniprot IDs		Q96CF2	P40818
PDB IDs		3C3R	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Viral Budding Via Host ESCRT Complex Viral Budding Cell Separation After Cytokinesis Virion Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Membrane Budding Protein Catabolic Process Mitotic Metaphase Plate Congression Proteolysis Cellular Macromolecule Catabolic Process Metaphase Plate Congression Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Chromosome Localization Viral Life Cycle Vesicle Organization Mitotic Cell Cycle Process Mitotic Sister Chromatid Segregation Posttranslational Protein Targeting To Membrane Mitotic Cell Cycle Sister Chromatid Segregation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cytokinesis Negative Regulation Of Macroautophagy Nucleus Organization Catabolic Process Regulation Of Autophagic Vacuole Assembly Cell Cycle Process Regulation Of Vacuole Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Viral Process Negative Regulation Of Neuron Death Endosomal Transport Cell Cycle Negative Regulation Of Autophagy Chromosome Segregation Regulation Of Centrosome Duplication Mitotic Cytokinesis Regulation Of Neuron Death Regulation Of Centrosome Cycle Cellular Protein Metabolic Process Membrane Organization Mitotic Nuclear Division Establishment Of Organelle Localization Positive Regulation Of Exocytosis Vacuolar Transport	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		attained conceptually dba deg degs domestication dudeg dudegs ehh eif4a3 foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		attained conceptually dba deg degs domestication dudeg dudegs ehh eif4a3 foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?