USP8 and GNAL

Data Source: HiPPIP (Novel)

		USP8	GNAL
Name		ubiquitin specific peptidase 8	G protein subunit alpha L
Structure
GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Response To Amphetamine Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Response To Caffeine
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway Olfactory Signaling Pathway
GWAS		Ankylosing spondylitis ( 30946743 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Mean reticulocyte volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 )	Age at first sexual intercourse ( 27089180 ) Alcohol dependence ( 26365420 ) Metabolite levels ( 23823483 ) QT interval (drug interaction) ( 23459443 ) Sensation seeking ( 30718321 ) Tandem gait ( 26219847 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Novel Interactors		1 novel interactors: GNAL	6 novel interactors: DOCK2 KCNH3 MIF TAF3 USP8 WASL
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	None recorded
Entrez ID		9101	2774
HPRD ID		04405	00758
Ensembl ID		ENSG00000138592	ENSG00000141404
Uniprot IDs		A8K8N5 P40818	A8K1Y9 P38405
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	8EL8 8IW1 8KGK 8KH4
GO Terms Enriched among Interactors		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	Negative Regulation Of Leukocyte Migration Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Endocytosis Membrane Raft Polarization Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Mononuclear Cell Migration Phenylpyruvate Tautomerase Activity Positive Regulation Of Arachidonate Secretion Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Regulation Of Signal Transduction By P53 Class Mediator Dopachrome Isomerase Activity Negative Regulation Of Mature B Cell Apoptotic Process Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive T Cell Selection Positive Regulation Of Cellular Component Organization Membrane Raft Distribution Positive Thymic T Cell Selection T Cell Receptor Binding Positive Regulation Of Transport Locomotion Immunological Synapse Formation Small GTPase-mediated Signal Transduction Alpha-beta T Cell Proliferation Actin Cytoskeleton Organization Pinocytosis Macropinocytosis Negative Thymic T Cell Selection Negative T Cell Selection Membrane Raft Localization Plasma Membrane Chemotaxis Regulation Of Endocytosis Establishment Of T Cell Polarity Regulation Of Leukocyte Migration Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Prostanoid Biosynthetic Process Regulation Of Arachidonate Secretion Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Macrophage Migration Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Macrophage Chemotaxis Protein Homotrimerization