USP8 and CD274

Number of citations of the paper that reports this interaction (PubMedID 36539510)
38

Data Source:
BioGRID (pull down)

		USP8	CD274
Description		ubiquitin specific peptidase 8	CD274 molecule
Image
GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Extracellular Region Nucleus Nucleoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Transcription Coactivator Activity Protein Binding Receptor Ligand Activity
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Adaptive Immune Response Immune System Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Activation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	Co-inhibition by PD-1 STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) translation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs			Sildenafil Valproic acid Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Camrelizumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	14 interacting genes: ANXA1 CD80 COPS5 CSNK2A1 DCAF1 HMGA1 HUWE1 ITGB1 OTUB1 PDCD1 TMUB1 UBQLN4 USP5 USP8
Entrez ID		9101	29126
HPRD ID		04405	05655
Ensembl ID		ENSG00000138592	ENSG00000120217
Uniprot IDs		A8K8N5 P40818	Q0GN75 Q9NZQ7
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR 7BEA 7C88 7CZD 7DCV 7DY7 7NLD 7OUN 7SJQ 7TPS 7UX5 7UXO 7UXP 7UXQ 7VUN 7XAD 7XAE 7XYQ 7YDS 8ALX 8AOK 8AOM 8JBA 8K5N 8OR1 8P1O 8R6Q 8RPB 8XR5 9INU
Enriched GO Terms of Interacting Partners?		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	Protein Metabolic Process Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Double-strand Break Repair Protein Modification By Small Protein Removal Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of DNA Repair Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Leukocyte Cell-cell Adhesion DeNEDDylase Activity Negative Regulation Of Lymphocyte Activation Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Leukocyte Activation DNA Metabolic Process Protein Modification Process Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Cell Activation Regulation Of Adaptive Immune Response Negative Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Negative Regulation Of Immune Response To Tumor Cell Cysteine-type Deubiquitinase Activity DNA Repair Negative Regulation Of Apoptotic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Deubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Mediated Immunity Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Adhesion Regulation Of Metabolic Process Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Metabolic Process Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of T-helper Cell Differentiation Proteolysis Involved In Protein Catabolic Process
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