USP8 and CHMP1A

Number of citations of the paper that reports this interaction (PubMedID 19302785)
0

Data Source:
BioGRID (pull down)

		USP8	CHMP1A
Description		ubiquitin specific peptidase 8	charged multivesicular body protein 1A
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GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Autophagosome Membrane Kinetochore Condensed Nuclear Chromosome ESCRT III Complex Nucleus Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Early Endosome Multivesicular Body Microtubule Organizing Center Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Nuclear Matrix Midbody Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Protein Binding Metallopeptidase Activity Zinc Ion Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Chromosome Condensation Mitotic Metaphase Chromosome Alignment Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Protein Transport Vesicle-mediated Transport Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	HCMV Late Events
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)	Basal cell carcinoma ( 33549134) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Estimated glomerular filtration rate ( 31152163) Hemoglobin levels ( 32327693) Low tan response ( 29739929) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Plasma homocysteine levels ( 30339177) Red vs. brown/black hair color ( 30531825)
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	18 interacting genes: C14orf119 CHMP1B DDIT4L GORASP2 LNPK MITD1 NR1I2 PSMA1 SDCBP STAMBP TXN2 UBE2I USP8 VPS4A VPS4B VTA1 YES1 ZDHHC17
Entrez ID		9101	5119
HPRD ID		04405	01237
Ensembl ID		ENSG00000138592	ENSG00000131165
Uniprot IDs		A8K8N5 P40818	A0A6Q8PFX8 Q9HD42
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	2JQ9 2YMB 4A5X
Enriched GO Terms of Interacting Partners?		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	ESCRT III Complex Disassembly ESCRT Complex Disassembly Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Midbody Abscission Nuclear Membrane Reassembly Viral Budding Mitotic Cytokinetic Process Endosome Organization Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Viral Budding From Plasma Membrane Membrane Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Midbody Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Nuclear Pore Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Endosome Membrane Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Vesicle Organization Membrane Fission Protein-containing Complex Disassembly Viral Process Mitotic Metaphase Chromosome Alignment Late Endosome Membrane Autophagosome Maturation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Metaphase Chromosome Alignment Mitotic Cytokinesis Mitotic Nuclear Membrane Reassembly ATPase Complex Chromosome Localization Cell Division Extracellular Exosome Positive Regulation Of Exocytosis Nucleus Organization Proteolysis
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