USP8 and BIRC6

Number of citations of the paper that reports this interaction (PubMedID 18329369)
0

Data Source:
HPRD (in vivo)

		USP8	BIRC6
Description		ubiquitin specific peptidase 8	baculoviral IAP repeat containing 6
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GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Spindle Pole Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Midbody Flemming Body
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Transferase Activity Peptidase Inhibitor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Placenta Development Protein Phosphorylation Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)	Chronotype ( 30696823) Coffee consumption ( 31046077) General risk tolerance (MTAG) ( 30643258) Male-pattern baldness ( 28196072) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	29 interacting genes: ARIH1 BIRC2 BIRC5 CASP3 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 GABARAP HTRA2 MAP1LC3B MAP2K1 NEDD4 PLK1 RAB8A RACK1 RNF144A RNF4 RNF41 UBA6 UBC UBE2D1 UBE3C USP8 VAV2 VCL
Entrez ID		9101	57448
HPRD ID		04405	05731
Ensembl ID		ENSG00000138592	ENSG00000115760
Uniprot IDs		A8K8N5 P40818	A0A8V8TQB4 A0A8V8TR92 Q9NR09
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	3CEG 8ATM 8ATO 8ATU 8ATX 8AUK 8AUW 8E2D 8E2E 8E2F 8E2G 8E2H 8E2I 8E2K
Enriched GO Terms of Interacting Partners?		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	Post-translational Protein Modification Protein Ubiquitination Proteolysis Cytosol Protein Modification By Small Protein Conjugation Protein Modification Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Catabolic Process Programmed Cell Death Cell Death Midbody Mitotic Cytokinesis Response To Anesthetic Execution Phase Of Apoptosis Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Protein Polyubiquitination Cytoskeleton-dependent Cytokinesis Response To Cobalt Ion CD40 Receptor Complex Regulation Of Macroautophagy Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Protein Localization Cytoplasm Transferase Activity Regulation Of Protein Catabolic Process Golgi Inheritance Positive Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Cysteine-type Endopeptidase Activity DNA Damage Response Cellular Response To Stress Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Localization To Site Of Double-strand Break Macromolecule Metabolic Process
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