USP8 and NTRK2

Number of citations: 52 (PubMedID 33288548)
Data Source: BioGRID (enzymatic study)

		USP8	NTRK2
Name		ubiquitin specific peptidase 8	neurotrophic receptor tyrosine kinase 2
Structure
GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor Receptor Activity
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Vasculogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Regulation Of Metabolic Process Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Cell Differentiation Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Retina Development In Camera-type Eye Long-term Synaptic Potentiation Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Negative Regulation Of Amyloid-beta Formation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	PIP3 activates AKT signaling NGF-independant TRKA activation Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs		None	Amitriptyline Esketamine Entrectinib Fostamatinib Larotrectinib
Diseases		None	Neuroblastoma
GWAS		Ankylosing spondylitis ( 30946743 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Mean reticulocyte volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 )	Birth weight ( 24950379 ) Body mass index ( 25760438 28892062 ) Body size at age 10 ( 32376654 ) Gout (normal type) ( 32238385 ) Lifetime anxiety disorder ( 31748690 ) Menarche (age at onset) ( 25231870 ) Parkinson's disease progression (cognitive) ( 33111402 ) Refractive error ( 32231278 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Type 2 diabetes ( 31118516 ) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594 )
Novel Interactors		1 novel interactors: GNAL	3 novel interactors: CDK20 KCNS1 NXNL2
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	35 interacting genes: AP1B1 BDNF DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TRAF6 UBB USP8
Entrez ID		9101	4915
HPRD ID		04405	02712
Ensembl ID		ENSG00000138592	ENSG00000148053
Uniprot IDs		A8K8N5 P40818	A0A8I5KR47 A0A8I5KUZ1 A0A8I5KZB7 A0A8J8YUT9 Q16620 Q548C2 Q5VWE5
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9 8OYD
GO Terms Enriched among Interactors		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Nerve Growth Factor Signaling Pathway Neurotrophin TRKA Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Response To Growth Factor Regulation Of Protein Localization Cell Projection Organization Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Intracellular Signal Transduction Cytosol Nerve Growth Factor Receptor Binding Response To Epidermal Growth Factor Insulin Receptor Binding Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Ephrin Receptor Binding Negative Regulation Of Developmental Process Signaling Adaptor Activity Modulation Of Chemical Synaptic Transmission Regulation Of Cell Population Proliferation Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cellular Localization Neuron Projection Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of PERK-mediated Unfolded Protein Response Cell Projection Morphogenesis Regulation Of ERK1 And ERK2 Cascade Endosome Membrane