CHMP4C and CHMP4A

Number of citations: 73 (PubMedID 35831314)
Data Source: BioGRID (biochemical), HPRD (two hybrid)

		CHMP4C	CHMP4A
Name		charged multivesicular body protein 4C	charged multivesicular body protein 4A
Structure
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Late Endosome Membrane Multivesicular Body Membrane Flemming Body Amphisome Membrane	Autophagosome Membrane Kinetochore ESCRT III Complex Nucleus Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Amphisome Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity ATPase Binding
	Biological Process	Plasma Membrane Repair Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Nuclear Membrane Reassembly Negative Regulation Of Cytokinesis Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Signaling Viral Budding From Plasma Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport	Plasma Membrane Repair Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Protein Transport Macroautophagy Nuclear Membrane Reassembly Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane Nervous System Process Protein Polymerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Plasma Membrane Tubulation Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport
Pathways		Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
GWAS		Age-related hearing impairment ( 34108613 ) Epithelial ovarian cancer ( 25581431 ) Ovarian cancer ( 23535730 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: CC2D1A CHMP4A CHMP4B HMGB3P1 PDCD6IP STAMBP TRPC4AP USP54 USP8 VPS4A	14 interacting genes: CC2D1A CDK13 CHMP3 CHMP4B CHMP4C CHMP5 CHMP6 NTAQ1 NUTF2 PDCD6IP STAMBP SYT17 TTC19 VPS4A
Entrez ID		92421	29082
HPRD ID		18135	16597
Ensembl ID		ENSG00000164695	ENSG00000254505
Uniprot IDs		Q96CF2	Q9BY43
PDB IDs		3C3R 5MK3 5V3R 5WA1	3C3O 5MK1
GO Terms Enriched among Interactors		Endosome Organization Cytoskeleton-dependent Cytokinesis Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Cytokinetic Process Vesicle Organization Mitotic Metaphase Chromosome Alignment Proteolysis Metaphase Chromosome Alignment Mitotic Cytokinesis Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Chromosome Localization Late Endosome To Lysosome Transport Nucleus Organization Regulation Of Mitotic Spindle Assembly Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Vesicle Budding From Membrane Viral Process Late Endosome To Vacuole Transport Endosome Macroautophagy Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Midbody Nuclear Membrane Organization Autophagosome Maturation Membrane Assembly Nuclear Pore ESCRT III Complex Amphisome Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Fusion With Vacuole Autophagy Multivesicular Body-lysosome Fusion Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Vesicle Fusion Protein Metabolic Process	Viral Budding Via Host ESCRT Complex Midbody Abscission Viral Budding Mitotic Cytokinetic Process Multivesicular Body Assembly Viral Budding From Plasma Membrane Multivesicular Body Organization Endosome Organization Cytokinetic Process Mitotic Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Regulation Of Mitotic Spindle Assembly Metaphase Chromosome Alignment Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Regulation Of Spindle Assembly Multivesicular Body-lysosome Fusion Chromosome Localization Nuclear Pore Late Endosome To Vacuole Transport Lysosomal Membrane Organization Nucleus Organization Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Kinetochore Microtubule Membrane Assembly Viral Process Multivesicular Body Membrane Vesicle Organization Vesicle Budding From Membrane Midbody Vesicle Fusion Organelle Membrane Fusion Multivesicular Body Regulation Of Centrosome Duplication Plasma Membrane Organization Lysosomal Transport Autophagosome Membrane Organelle Fusion Regulation Of Centrosome Cycle