CHMP4C and TRPC4AP

Number of citations of the paper that reports this interaction (PubMedID 16730941)
0

Data Source:
HPRD (two hybrid)

		CHMP4C	TRPC4AP
Description		charged multivesicular body protein 4C	transient receptor potential cation channel subfamily C member 4 associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Late Endosome Membrane Multivesicular Body Membrane Flemming Body Amphisome Membrane	Cytoplasm Cytosol Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity	Calcium Channel Activity Protein Binding Phosphatase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Plasma Membrane Repair Vesicle Budding From Membrane Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Macroautophagy Nuclear Membrane Reassembly Negative Regulation Of Cytokinesis Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Signaling Viral Budding From Plasma Membrane Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Hair Follicle Maturation Calcium Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	TRP channels
Drugs
Diseases
GWAS		Age-related hearing impairment ( 34108613) Epithelial ovarian cancer ( 25581431) Ovarian cancer ( 23535730)	Basal cell carcinoma ( 33549134) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Prothrombin time ( 22703881) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CC2D1A CHMP4A CHMP4B HMGB3P1 PDCD6IP STAMBP TRPC4AP USP54 USP8 VPS4A	10 interacting genes: CHMP4C CHUK IKBKB IKBKG MTDH RIPK1 TAB1 TNFRSF1A TRADD TRAF2
Entrez ID		92421	26133
HPRD ID		18135	09238
Ensembl ID		ENSG00000164695	ENSG00000100991
Uniprot IDs		Q96CF2	B4DW48 Q8TEL6
PDB IDs		3C3R 5MK3 5V3R 5WA1
Enriched GO Terms of Interacting Partners?		Endosome Organization Cytoskeleton-dependent Cytokinesis Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Cytokinetic Process Vesicle Organization Mitotic Metaphase Chromosome Alignment Proteolysis Metaphase Chromosome Alignment Mitotic Cytokinesis Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Chromosome Localization Late Endosome To Lysosome Transport Nucleus Organization Regulation Of Mitotic Spindle Assembly Nuclear Membrane Reassembly Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Vesicle Budding From Membrane Viral Process Late Endosome To Vacuole Transport Endosome Macroautophagy Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Multivesicular Body Sorting Pathway Midbody Nuclear Membrane Organization Autophagosome Maturation Membrane Assembly Nuclear Pore ESCRT III Complex Amphisome Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Fusion With Vacuole Autophagy Multivesicular Body-lysosome Fusion Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Vesicle Fusion Protein Metabolic Process	Non-canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Transferrin Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor IkappaB Kinase Activity Death Domain Binding Positive Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Tumor Necrosis Factor Binding Death-inducing Signaling Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Receptor Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response Inflammatory Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Establishment Of Endothelial Barrier Regulation Of Signal Transduction Defense Response Positive Regulation Of Execution Phase Of Apoptosis Programmed Necrotic Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Immune System Process Protein Heterodimerization Activity Innate Immune Response
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