USP8 and STAM

Number of citations: 0 (PubMedID 10982817)
Data Source: HPRD (in vitro, in vivo)

		USP8	STAM
Name		ubiquitin specific peptidase 8	signal transducing adaptor molecule
Structure
GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane ESCRT-0 Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
GWAS		Ankylosing spondylitis ( 30946743 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Mean reticulocyte volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GNAL	1 novel interactors: MAD1L1
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	21 interacting genes: HGS JAK1 JAK2 JAK3 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL RIPK4 SNCA STAMBP TIMM8A TRIM54 TRIM55 TRIM63 USP15 USP28 USP8 WWP2
Entrez ID		9101	8027
HPRD ID		04405	03542
Ensembl ID		ENSG00000138592	ENSG00000136738
Uniprot IDs		A8K8N5 P40818	B4DZT2 Q92783
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	2L0A 3F1I 3LDZ
GO Terms Enriched among Interactors		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	Protein Modification Process Protein Metabolic Process Post-translational Protein Modification Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Endosome Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Deubiquitinase Activity Ubiquitin Protein Ligase Activity Protein Deubiquitination Cytoplasm Protein Modification By Small Protein Removal Regulation Of Signal Transduction Metal Ion Binding Macromolecule Metabolic Process Transferase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transduction Interleukin-4-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Signal Transduction PTW/PP1 Phosphatase Complex Interleukin-9-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cytosol Interleukin-2-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Type II Interferon-mediated Signaling Pathway Protein Domain Specific Binding Interleukin-6-mediated Signaling Pathway Postsynapse Cysteine-type Deubiquitinase Activity K63-linked Deubiquitinase Activity Protein Phosphatase Binding K48-linked Deubiquitinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Cytoplasmic Side Of Plasma Membrane Protein Kinase Activity Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding