USP8 and SLBP

Number of citations of the paper that reports this interaction (PubMedID 10982817)
0

Data Source:
HPRD (in vitro)

		USP8	SLBP
Description		ubiquitin specific peptidase 8	stem-loop histone mRNA binding protein
Image
GO Annotations	Cellular Component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Histone MRNA Stem-loop Binding Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding
	Biological Process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus	Cap-dependent Translational Initiation MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Transport
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Hip minimal joint space width ( 27701424) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		49 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	12 interacting genes: CDK1 CDK2 CDK4 CDK6 CEBPA CSNK2A1 DCAF11 ERI1 LSM10 PTGER4 USP8 ZNF473
Entrez ID		9101	7884
HPRD ID		04405	03884
Ensembl ID		ENSG00000138592	ENSG00000163950
Uniprot IDs		A8K8N5 P40818	B3KSC5 B3KST9 B4DUW7 E7EUV9 Q14493 Q53XR2
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A	2KJM 4L8R 4QOZ
Enriched GO Terms of Interacting Partners?		Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody	Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Histone MRNA Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Histone Kinase Activity MRNA 3'-end Processing By Stem-loop Binding And Cleavage Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Process Cajal Body Response To Ketone Cellular Response To Oxygen-containing Compound Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity RNA 3'-end Processing Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Hemopoiesis Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response
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