USP8 and DNAJB6

Number of citations of the paper that reports this interaction (PMID 15342353)
8

Data Source:
HPRD (in vitro)

		USP8	DNAJB6
Gene Name		ubiquitin specific peptidase 8	DnaJ (Hsp40) homolog, subfamily B, member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding	ATPase Activator Activity Protein Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Protein Folding Positive Regulation Of ATPase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Organization Negative Regulation Of Inclusion Body Assembly
Pathways		Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ	6 interactors: APP BRMS1 KRT18 PIK3CA POLR1D USP8
Entrez ID		9101	10049
HPRD ID		04405	07107
Ensembl ID		ENSG00000138592	ENSG00000105993
Uniprot IDs		P40818	B4DN73 E9PH18 O75190
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport	Regulation Of Anoikis Regulation Of Multicellular Organism Growth Golgi To Plasma Membrane CFTR Protein Transport Hypomethylation Of CpG Island Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Protein Metabolic Process Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Metabolic Process Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Positive Regulation Of Anoikis Platelet Activation Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Genetic Imprinting Cell Death Death Axon Choice Point Recognition Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Developmental Growth Neuron Remodeling Positive Regulation Of Protein Metabolic Process Negative Regulation Of Fibroblast Apoptotic Process Immune Response Defense Response Negative Regulation Of Anoikis Vesicle-mediated Transport Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Apoptotic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Cellular Protein Modification Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Regulation Of Cell Death Endomembrane System Organization Regulation Of DNA Methylation Regulation Of Fibroblast Apoptotic Process Hepatocyte Apoptotic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Golgi To Plasma Membrane Protein Transport Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination	alphab bag3 biomechanical carrying crystallin deformation desmin disability fhl fiber filamin hereditary mechanical mfms myoblasts myofibrillar myopathies myotilin physiologic plectin premature shear sporadic stiffness stretch trigger vcp vulnerability zasp
Tagcloud (Difference) ?		ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination	alphab bag3 biomechanical carrying crystallin deformation desmin disability fhl fiber filamin hereditary mechanical mfms myoblasts myofibrillar myopathies myotilin physiologic plectin premature shear sporadic stiffness stretch trigger vcp vulnerability zasp
Tagcloud (Intersection) ?