CHMP4C and VPS4A

Number of citations of the paper that reports this interaction (PMID 14505570)
292

Data Source:
HPRD (two hybrid)

		CHMP4C	VPS4A
Gene Name		charged multivesicular body protein 4C	vacuolar protein sorting 4 homolog A (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Midbody Late Endosome Membrane Extracellular Vesicular Exosome Flemming Body	ESCRT III Complex Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Flemming Body
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled
	Biological Process	Cell Separation After Cytokinesis Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Abscission Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Negative Regulation Of Cytokinesis Regulation Of Viral Process Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell	Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Protein Transport Viral Process Vesicle-mediated Transport Endosomal Transport Viral Life Cycle Cytoplasmic Microtubule Organization Negative Regulation Of Cytokinesis Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)
Protein-Protein Interactions		10 interactors: CC2D1A CHMP4A CHMP4B HMGB3P1 PDCD6IP STAMBP TRPC4AP USP54 USP8 VPS4A	9 interactors: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C NPC1 RND2 VPS4B
Entrez ID		92421	27183
HPRD ID		18135	11676
Ensembl ID		ENSG00000164695	ENSG00000132612
Uniprot IDs		Q96CF2	Q9UN37
PDB IDs		3C3R	1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?		Viral Budding Via Host ESCRT Complex Viral Budding Cell Separation After Cytokinesis Virion Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Division Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Membrane Budding Protein Catabolic Process Mitotic Metaphase Plate Congression Proteolysis Cellular Macromolecule Catabolic Process Metaphase Plate Congression Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Chromosome Localization Viral Life Cycle Vesicle Organization Mitotic Cell Cycle Process Mitotic Sister Chromatid Segregation Posttranslational Protein Targeting To Membrane Mitotic Cell Cycle Sister Chromatid Segregation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cytokinesis Negative Regulation Of Macroautophagy Nucleus Organization Catabolic Process Regulation Of Autophagic Vacuole Assembly Cell Cycle Process Regulation Of Vacuole Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Viral Process Negative Regulation Of Neuron Death Endosomal Transport Cell Cycle Negative Regulation Of Autophagy Chromosome Segregation Regulation Of Centrosome Duplication Mitotic Cytokinesis Regulation Of Neuron Death Regulation Of Centrosome Cycle Cellular Protein Metabolic Process Membrane Organization Mitotic Nuclear Division Establishment Of Organelle Localization Positive Regulation Of Exocytosis Vacuolar Transport	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Mitotic Metaphase Plate Congression Regulation Of Spindle Assembly Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Regulation Of Centrosome Duplication Nucleus Organization Regulation Of Centrosome Cycle Viral Budding Via Host ESCRT Complex Chromosome Segregation Positive Regulation Of Viral Release From Host Cell Viral Budding Regulation Of Mitotic Nuclear Division Mitotic Nuclear Division Establishment Of Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Organelle Localization Cell Division Regulation Of Viral Release From Host Cell Virion Assembly Regulation Of Cell Division Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Process Regulation Of Protein Complex Assembly Mitotic Cell Cycle Establishment Of Protein Localization Regulation Of Mitotic Cell Cycle Intracellular Transport Viral Life Cycle Regulation Of Organelle Organization Regulation Of Cell Cycle Process Endosomal Transport Regulation Of Cytoskeleton Organization Chromosome Organization Positive Regulation Of Viral Process Cell Cycle Process Negative Regulation Of Macroautophagy Membrane Budding Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Cell Cycle Protein Transport Cellular Localization
Tagcloud ?		attained conceptually dba deg degs domestication dudeg dudegs ehh eif4a3 foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592	aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Difference) ?		attained conceptually dba deg degs domestication dudeg dudegs ehh eif4a3 foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592	aip1 budding detail dn e3 escrt gag htlv infant invagination mother motif multivesicular mvb nedd4 polyprotein pppy ptap sorting tsg101 utilizes vertical vesicles vlps vps28 vps37 vps4b ww
Tagcloud (Intersection) ?