CD5 and ZAP70

Number of citations of the paper that reports this interaction (PubMedID 9378960)
0

Data Source:
HPRD (in vivo)

		CD5	ZAP70
Description		CD5 molecule	zeta chain of T cell receptor associated protein kinase 70
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Protein Binding Signaling Receptor Activity	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway	Adaptive Immune Response Immune System Process Protein Phosphorylation Immune Response Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration T Cell Aggregation T Cell Migration
Pathways			Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle Nuclear events stimulated by ALK signaling in cancer
Drugs			Staurosporine Fostamatinib
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088 24076602) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: CAMK2D CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CSNK2A1 DYNLT3 FYN HNRNPU LCK PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70	67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PELI1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		921	7535
HPRD ID		01078	01495
Ensembl ID		ENSG00000110448	ENSG00000115085
Uniprot IDs		P06127	P43403
PDB IDs		2JA4 2JOP 2JP0 2OTT	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76 7SIY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Plasma Membrane Leukocyte Activation Signal Transduction Positive Regulation Of Immune System Process Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Adaptive Immune Response Regulation Of Immune System Process T Cell Receptor Complex B Cell Receptor Signaling Pathway Cell-cell Junction Immune Response-activating Signaling Pathway Immune Response Regulation Of Immune Response Signaling Receptor Binding Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Regulation Of Apoptotic Process Protein Kinase Activity Identical Protein Binding T Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Intracellular Signal Transduction Membrane Raft Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Lymphocyte Differentiation Phosphatidylinositol 3-kinase Binding Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of T Cell Activation Kinase Activity Regulation Of Hemopoiesis Negative Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Cell-cell Adhesion	Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Signal Transduction Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Immune System Process Lymphocyte Activation Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune System Process Regulation Of T Cell Activation Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction T Cell Activation Intracellular Signal Transduction Activation Of Immune Response Plasma Membrane Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Membrane Raft Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Leukocyte Proliferation Regulation Of T Cell Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction SH3 Domain Binding Negative Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Lymphocyte Proliferation Positive Regulation Of Multicellular Organismal Process Mononuclear Cell Proliferation
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