CD5 and ZNHIT2

Data Source: HiPPIP (Novel)

		CD5	ZNHIT2
Name		CD5 molecule	zinc finger HIT-type containing 2
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	None
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway	None
GWAS		Coffee consumption ( 31046077 ) Gut microbiota (bacterial taxa) ( 27694959 ) Gut microbiota (functional units) ( 27694959 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Rheumatoid arthritis ( 23143596 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: CAMK2D CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CSNK2A1 DYNLT3 FYN HNRNPU LCK PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70	5 interacting genes: CD2BP2 JAKMIP1 KRTAP22-1 LONRF1 OGT
Entrez ID		921	741
HPRD ID		01078	05200
Ensembl ID		ENSG00000110448	ENSG00000174276
Uniprot IDs		P06127	Q9UHR6
PDB IDs		2JA4 2JOP 2JP0 2OTT	1X4S
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Plasma Membrane Leukocyte Activation Signal Transduction Positive Regulation Of Immune System Process Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Adaptive Immune Response Regulation Of Immune System Process T Cell Receptor Complex B Cell Receptor Signaling Pathway Cell-cell Junction Immune Response-activating Signaling Pathway Immune Response Regulation Of Immune Response Signaling Receptor Binding Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Regulation Of Apoptotic Process Protein Kinase Activity Identical Protein Binding T Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Intracellular Signal Transduction Membrane Raft Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Lymphocyte Differentiation Phosphatidylinositol 3-kinase Binding Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of T Cell Activation Kinase Activity Regulation Of Hemopoiesis Negative Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Cell-cell Adhesion	None