CD5 and CD6

Number of citations: 0 (PubMedID 12473675)
Data Source: HPRD (in vivo, in vitro)

		CD5	CD6
Name		CD5 molecule	CD6 molecule
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Immunological Synapse Extracellular Region Plasma Membrane Cell Surface Membrane T Cell Receptor Complex
	Molecular Function	Protein Binding Signaling Receptor Activity	Lipopolysaccharide Binding Protein Binding Protein Kinase Binding Identical Protein Binding Lipoteichoic Acid Binding
	Biological Process	Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway	Immunological Synapse Formation Adaptive Immune Response Immune System Process Acute Inflammatory Response To Antigenic Stimulus Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response
GWAS		Coffee consumption ( 31046077 ) Gut microbiota (bacterial taxa) ( 27694959 ) Gut microbiota (functional units) ( 27694959 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Rheumatoid arthritis ( 23143596 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Gut microbiota (bacterial taxa) ( 27694959 ) Gut microbiota (functional units) ( 27694959 ) Inflammatory bowel disease ( 23128233 28067908 ) Lymphocyte count ( 32888494 ) Multiple sclerosis ( 19525953 21244703 21833088 24076602 31604244 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Interacting Genes		21 interacting genes: CAMK2D CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CSNK2A1 DYNLT3 FYN HNRNPU LCK PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70	5 interacting genes: ALCAM CD5 GYG1 NFE2L1 SDCBP
Entrez ID		921	923
HPRD ID		01078	01724
Ensembl ID		ENSG00000110448	ENSG00000013725
Uniprot IDs		P06127	P30203 Q6AZ88 Q8N4Q7
PDB IDs		2JA4 2JOP 2JP0 2OTT	5A2E
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Plasma Membrane Leukocyte Activation Signal Transduction Positive Regulation Of Immune System Process Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Adaptive Immune Response Regulation Of Immune System Process T Cell Receptor Complex B Cell Receptor Signaling Pathway Cell-cell Junction Immune Response-activating Signaling Pathway Immune Response Regulation Of Immune Response Signaling Receptor Binding Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Regulation Of Apoptotic Process Protein Kinase Activity Identical Protein Binding T Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Intracellular Signal Transduction Membrane Raft Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Lymphocyte Differentiation Phosphatidylinositol 3-kinase Binding Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of T Cell Activation Kinase Activity Regulation Of Hemopoiesis Negative Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Cell-cell Adhesion	None