DDX21 and ERG

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DDX21	ERG
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 21	v-ets avian erythroblastosis virus E26 oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane	Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Double-stranded RNA Binding ATP-dependent RNA Helicase Activity ATP Binding Poly(A) RNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Osteoblast Differentiation Metabolic Process Response To Virus Response To Exogenous DsRNA	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)
Protein-Protein Interactions		11 interactors: CALM1 CSNK2A1 ERG H2AFX IL7R JUN KPNA3 PIAS1 SRPK2 TERF1 TERF2	61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2
Entrez ID		9188	2078
HPRD ID		05895	01298
Ensembl ID		ENSG00000165732	ENSG00000157554
Uniprot IDs		Q9NR30	B4DN83 B4DVX5 P11308
PDB IDs		2M3D	1SXE 4IRG 4IRH 4IRI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Response To Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of DNA Replication Regulation Of Telomere Maintenance Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Proteasomal Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic Spindle Checkpoint Immune Response Negative Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Regulation Of Cell Division Response To Cytokine Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of DNA Replication Negative Regulation Of Ion Transmembrane Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Transmembrane Transport Cellular Nitrogen Compound Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aging Negative Regulation Of Proteasomal Protein Catabolic Process	MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly
Tagcloud ?		agar ap array bioluminescence correlates helicase herein immunofluorescence indirect jun localization luciferase lymphomas markedly mechanistically nucleolar processing promote qrt ribosome rrna ser73 soft subcellular subset tumorigenesis tumorigenicity undergo xenograft	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?		agar ap array bioluminescence correlates helicase herein immunofluorescence indirect jun localization luciferase lymphomas markedly mechanistically nucleolar processing promote qrt ribosome rrna ser73 soft subcellular subset tumorigenesis tumorigenicity undergo xenograft	antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?