DDX21 and H2AFX

Number of citations of the paper that reports this interaction (PMID 23145133)
4

Data Source:
BioGRID (pull down)

		DDX21	H2AFX
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 21	H2A histone family, member X
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane	Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Site Of Double-strand Break Extracellular Vesicular Exosome
	Molecular Function	Double-stranded RNA Binding ATP-dependent RNA Helicase Activity ATP Binding Poly(A) RNA Binding	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation Metabolic Process Response To Virus Response To Exogenous DsRNA	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Positive Regulation Of DNA Repair Meiotic Cell Cycle
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends RNF mutants show enhanced WNT signaling and proliferation Homologous recombination repair of replication-independent double-strand breaks ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance ATM mediated response to DNA double-strand break misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Chromatin organization formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Senescence-Associated Secretory Phenotype (SASP) Chromatin modifying enzymes Recruitment of repair and signaling proteins to double-strand breaks SIRT1 negatively regulates rRNA Expression Condensation of Prophase Chromosomes MRN complex relocalizes to nuclear foci RNA Polymerase I Promoter Clearance Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks M Phase Telomere Maintenance Nucleosome assembly XAV939 inhibits tankyrase, stabilizing AXIN Double-Strand Break Repair DNA methylation Transcriptional regulation by small RNAs Meiotic recombination RNA Polymerase I Transcription Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic PRC2 methylates histones and DNA RMTs methylate histone arginines TCF dependent signaling in response to WNT Oxidative Stress Induced Senescence Homologous Recombination Repair RNA Polymerase I Promoter Opening Signaling by WNT in cancer
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)
Protein-Protein Interactions		11 interactors: CALM1 CSNK2A1 ERG H2AFX IL7R JUN KPNA3 PIAS1 SRPK2 TERF1 TERF2	45 interactors: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 KAT5 MASP1 MCPH1 MDC1 MRE11A NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PPP2R4 PRKDC QARS RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TSSK6 WRN XRCC6
Entrez ID		9188	3014
HPRD ID		05895	03465
Ensembl ID		ENSG00000165732	ENSG00000188486
Uniprot IDs		Q9NR30	P16104
PDB IDs		2M3D	2D31 2DYP 3SHV 3SQD 3SZM 3U3Z
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Response To Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of DNA Replication Regulation Of Telomere Maintenance Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Proteasomal Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic Spindle Checkpoint Immune Response Negative Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Regulation Of Cell Division Response To Cytokine Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of DNA Replication Negative Regulation Of Ion Transmembrane Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Transmembrane Transport Cellular Nitrogen Compound Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aging Negative Regulation Of Proteasomal Protein Catabolic Process	DNA Metabolic Process Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Organization DNA Recombination Organelle Organization Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Chromatin Organization Response To Stress Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Modification Signal Transduction By P53 Class Mediator Response To Stimulus Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Stimulus Cellular Protein Modification Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification DNA Damage Checkpoint Peptidyl-lysine Modification Cell Cycle Process Regulation Of Cellular Protein Metabolic Process DNA Replication Regulation Of Gene Expression Response To Gamma Radiation Negative Regulation Of Protein Metabolic Process Histone Acetylation Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud ?		agar ap array bioluminescence correlates helicase herein immunofluorescence indirect jun localization luciferase lymphomas markedly mechanistically nucleolar processing promote qrt ribosome rrna ser73 soft subcellular subset tumorigenesis tumorigenicity undergo xenograft
Tagcloud (Difference) ?		agar ap array bioluminescence correlates helicase herein immunofluorescence indirect jun localization luciferase lymphomas markedly mechanistically nucleolar processing promote qrt ribosome rrna ser73 soft subcellular subset tumorigenesis tumorigenicity undergo xenograft
Tagcloud (Intersection) ?