DDX21 and DUX4

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		DDX21	DUX4
Description		DExD-box helicase 21	double homeobox 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane B-WICH Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding RNA Polymerase Inhibitor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Osteoblast Differentiation Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Chromatin Remodeling RRNA Processing Transcription By RNA Polymerase II Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Defense Response To Virus R-loop Processing	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)
Interacting Genes		88 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN RBFOX2 RPL34 SUMO2 TERF1 TERF2 UBE2I USP7	124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1
Entrez ID		9188	100288687
HPRD ID		05895
Ensembl ID		ENSG00000165732	ENSG00000260596
Uniprot IDs		A0A8I5KYZ4 Q9NR30	C3U3A0 Q9UBX2
PDB IDs		2M3D 6L5L 6L5M 6L5N 6L5O	5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of RNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding
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