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CD3E and UNC119
Number of citations of the paper that reports this interaction (PubMedID
14757743
)
20
Data Source:
HPRD
(in vitro)
CD3E
UNC119
Description
CD3 epsilon subunit of T-cell receptor complex
unc-119 lipid binding chaperone
Image
GO Annotations
Cellular Component
Immunological Synapse
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Gamma-delta T Cell Receptor Complex
Dendritic Spine
Cell Body
Spindle Pole
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Intercellular Bridge
Synapse
Spindle Midzone
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
T Cell Receptor Binding
Identical Protein Binding
Protein Binding
Lipid Binding
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Immune System Process
Positive Regulation Of T Cell Anergy
T Cell Anergy
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
G Protein-coupled Receptor Signaling Pathway
Smoothened Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Calcium-mediated Signaling
Cerebellum Development
T Cell Costimulation
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
CD4-positive, Alpha-beta T Cell Proliferation
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of Smoothened Signaling Pathway
Gamma-delta T Cell Activation
Alpha-beta T Cell Activation
Lymphocyte Activation
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Protein-containing Complex Assembly
Apoptotic Signaling Pathway
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Mitotic Cytokinesis
Endocytosis
Chemical Synaptic Transmission
Nervous System Development
Visual Perception
Phototransduction
Protein Transport
Lipoprotein Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Clathrin-dependent Endocytosis
Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
Co-inhibition by PD-1
Drugs
Muromonab
Teplizumab
Catumaxomab
Mosunetuzumab
Teclistamab
Odronextamab
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Lung cancer in ever smokers (
28604730
)
Pulse pressure (
27841878
)
Interacting Genes
26 interacting genes:
ADAM33
BNIP3
CD3D
CD3G
CD79B
CSK
EPS8L1
LCK
MUC15
NCK1
NCK2
NCL
PIK3R1
PKMYT1
POLR1G
PTPN22
SHC1
SNTA1
SYK
TOP2B
TRAT1
TRB
UBASH3A
UNC119
ZAP70
ZFPL1
104 interacting genes:
AAGAB
ALDH2
AMOT
ANKRD24
ANXA1
ANXA3
ANXA7
ARL15
ARL2
ARL3
ARL4D
ASH2L
BCR
BRIX1
BTBD2
C16orf74
CBX8
CCL18
CD247
CD3E
CD4
CDC42
CDKN1A
CDKN2C
CETN3
CFTR
CKMT2
CKS2
COX17
CYB561D2
EIF2S2
ERH
FKBPL
FXYD6
FYN
GIPC2
GSTM4
HCK
HLA-DQA1
HMGB1
HSPB3
HSPE1
ID2
IL5RA
ITSN1
KDM1A
KRTAP1-3
KRTAP9-3
KRTAP9-8
LAMA4
LCK
LIG4
LRIF1
LUC7L2
LYN
MAP3K20
MAPK10
MAPK8IP2
MPHOSPH6
MRPS12
ORAI2
PAFAH1B3
PAPSS1
PCDHA4
PFN1
PHF10
PIN1
PLPP2
PPA1
PPP3CA
PPP3CC
PSMD11
PSMD2
PTPRS
QTRT1
RAP1B
RASSF6
RBPMS2
RCAN3
RCC1
RFC5
RGL2
RPA2
RPS6KA5
RUFY3
S100A4
S100A8
SAT1
SEPHS1
SERPINB9
SMN1
SULT1E1
TK1
TMEM200A
TP53BP2
TP53I3
TP53INP1
TRDMT1
TSC22D1
UBE2B
UBE2I
UBQLN4
ZFP64
ZNF24
Entrez ID
916
9094
HPRD ID
08923
04927
Ensembl ID
ENSG00000198851
ENSG00000109103
Uniprot IDs
P07766
K7EN86
Q13432
PDB IDs
1A81
1SY6
1XIW
2ROL
5QU2
6JXR
7FJD
7FJE
7FJF
7PHR
8ES7
8ES8
8ES9
8F0L
8JC0
8JCB
8TW4
8TW6
8VY4
8WXE
8WY0
8WYI
8YC0
9BBC
9C3E
9CI8
9CIA
9CQ4
3GQQ
3RBQ
4GOJ
4GOK
5L7K
6H6A
7UMO
9GKG
Enriched GO Terms of Interacting Partners
?
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
T Cell Receptor Complex
Lymphocyte Activation
Phosphotyrosine Residue Binding
Regulation Of T Cell Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Leukocyte Activation
Regulation Of Immune Response
T Cell Activation
Cell Activation
Immune Response-activating Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Adaptive Immune Response
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Lymphocyte Differentiation
Alpha-beta T Cell Receptor Complex
T Cell Selection
Negative Regulation Of T Cell Receptor Signaling Pathway
Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Mononuclear Cell Differentiation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Thymic T Cell Selection
T Cell Receptor Binding
Positive T Cell Selection
Leukocyte Differentiation
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Gamma-delta T Cell Activation
T Cell Differentiation
Thymic T Cell Selection
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Beta Selection
Immune Response
Regulation Of Cell-cell Adhesion
B Cell Activation
Positive Regulation Of Cell-cell Adhesion
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Leukocyte Proliferation
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Glutamatergic Synapse
Leukocyte Migration
Positive Regulation Of Cell Activation
Cytosol
Enzyme Binding
Positive Regulation Of Cell-cell Adhesion
Protein Binding
T Cell Receptor Binding
RAGE Receptor Binding
Positive Regulation Of Cell Adhesion
Intracellular Signal Transduction
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Development
Regulation Of Calcium Ion Import Across Plasma Membrane
Cytoplasm
Nucleus
T Cell Activation
Positive Regulation Of Monoatomic Ion Transmembrane Transport
Gamma-delta T Cell Receptor Complex
Lymphocyte Activation
Regulation Of Leukocyte Cell-cell Adhesion
Calcium-dependent Protein Binding
Regulation Of T Cell Activation
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cellular Developmental Process
T Cell Costimulation
Positive Regulation Of Leukocyte Differentiation
T Cell Receptor Complex
Intracellular Signaling Cassette
CD8 Receptor Binding
Nucleotide Binding
Gamma-delta T Cell Activation
Negative Regulation Of Cell Development
Peptidyl-tyrosine Phosphorylation
Regulation Of Mitotic Cell Cycle
Phagocytosis
Regulation Of Leukocyte Proliferation
Response To Gamma Radiation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Schaffer Collateral - CA1 Synapse
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