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CD3E
Gene Name
CD3e molecule, epsilon (CD3-TCR complex)
Image
Gene Ontology Annotations
Cellular Component
Immunological Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Molecular Function
Transmembrane Signaling Receptor Activity
Receptor Signaling Protein Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Receptor Signaling Complex Scaffold Activity
T Cell Receptor Binding
Protein Heterodimerization Activity
Biological Process
Positive Regulation Of T Cell Anergy
Protein Complex Assembly
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
G-protein Coupled Receptor Signaling Pathway
Response To Nutrient
T Cell Costimulation
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-4 Production
Intracellular Signal Transduction
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of Apoptotic Process
Negative Thymic T Cell Selection
Positive Regulation Of Interleukin-2 Biosynthetic Process
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Apoptotic Signaling Pathway
Pathways
TCR signaling
Downstream TCR signaling
Generation of second messenger molecules
Translocation of ZAP-70 to Immunological synapse
Costimulation by the CD28 family
PD-1 signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Muromonab
Diseases
GWAS
Protein-protein Interactions
19 interactors:
CD3D
CD3EAP
CD3G
CD79B
CSK
LCK
NCK1
NCK2
NCL
PIK3R1
PTPN22
SHC1
SNTA1
SYK
TOP2B
TRAT1
TRB
UNC119
ZAP70
Entrez ID
916
HPRD ID
08923
Ensembl ID
ENSG00000198851
Uniprot IDs
P07766
PDB IDs
1A81
1SY6
1XIW
2ROL
Enriched GO Terms of Interacting Partners
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Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Lymphocyte Activation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Leukocyte Activation
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Single Organismal Cell-cell Adhesion
Immune System Process
Enzyme Linked Receptor Protein Signaling Pathway
Fc Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Innate Immune Response
T Cell Costimulation
Cell Migration
Cell Motility
Immune Response
Regulation Of Cellular Amino Acid Metabolic Process
Lymphocyte Differentiation
Peptidyl-tyrosine Autophosphorylation
Regulation Of Cellular Ketone Metabolic Process
Signal Transduction
Cell Adhesion
T Cell Differentiation
Locomotion
Positive Regulation Of Signal Transduction
Tagcloud
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acp5
b220
calcitonin
calcr
cd11b
cd2
cd31
cd45
cd5
ctsk
dcstamp
dentin
dihydroxyvitamin
dmp1
facs
gfp
gr1
haematopoietic
lin
mepe
oscar
osteocyte
osteocytes
resolve
sclerostin
sost
tartrate
ter119
tnfsf11