CD3E and CD3G

Number of citations of the paper that reports this interaction (PMID 2138083)
29

Data Source:
HPRD (in vitro)

		CD3E	CD3G
Gene Name		CD3e molecule, epsilon (CD3-TCR complex)	CD3g molecule, gamma (CD3-TCR complex)
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Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Receptor Signaling Protein Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of T Cell Anergy Protein Complex Assembly Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G-protein Coupled Receptor Signaling Pathway Response To Nutrient T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Negative Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Apoptotic Signaling Pathway	Protein Complex Assembly Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Lymphocyte Apoptotic Process
Pathways		TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse TCR signaling PD-1 signaling Role of phospholipids in phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Fcgamma receptor (FCGR) dependent phagocytosis Phosphorylation of CD3 and TCR zeta chains FCGR activation Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs		Muromonab
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CD3D CD3EAP CD3G CD79B CSK LCK NCK1 NCK2 NCL PIK3R1 PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UNC119 ZAP70	5 interactors: CD3D CD3E TRA TRB TRD
Entrez ID		916	917
HPRD ID		08923	07037
Ensembl ID		ENSG00000198851
Uniprot IDs		P07766	B0YIY5 P09693
PDB IDs		1A81 1SY6 1XIW 2ROL	1SY6
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response T Cell Costimulation Cell Migration Cell Motility Immune Response Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Ketone Metabolic Process Signal Transduction Cell Adhesion T Cell Differentiation Locomotion Positive Regulation Of Signal Transduction	Thymic T Cell Selection T Cell Selection T Cell Differentiation In Thymus T Cell Costimulation T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion T Cell Aggregation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Leukocyte Activation Positive Regulation Of T Cell Anergy Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Hemopoiesis Regulation Of T Cell Anergy Positive Regulation Of Immune Response Positive Thymic T Cell Selection Cell Activation Immune System Development Positive Regulation Of T Cell Tolerance Induction Negative Thymic T Cell Selection Signal Complex Assembly Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Negative T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-2 Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling
Tagcloud ?		acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11	aurkb bub1b ccnb1 cd247 cd3d cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?		acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11	aurkb bub1b ccnb1 cd247 cd3d cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?