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CD3E and SHC1
Number of citations of the paper that reports this interaction (PubMedID
11855827
)
0
Data Source:
HPRD
(in vitro)
CD3E
SHC1
Description
CD3 epsilon subunit of T-cell receptor complex
SHC adaptor protein 1
Image
GO Annotations
Cellular Component
Immunological Synapse
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Gamma-delta T Cell Receptor Complex
Dendritic Spine
Cell Body
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Focal Adhesion
Anchoring Junction
Shc-EGFR Complex
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
T Cell Receptor Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Immune System Process
Positive Regulation Of T Cell Anergy
T Cell Anergy
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
G Protein-coupled Receptor Signaling Pathway
Smoothened Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Calcium-mediated Signaling
Cerebellum Development
T Cell Costimulation
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
CD4-positive, Alpha-beta T Cell Proliferation
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of Smoothened Signaling Pathway
Gamma-delta T Cell Activation
Alpha-beta T Cell Activation
Lymphocyte Activation
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Protein-containing Complex Assembly
Apoptotic Signaling Pathway
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Angiogenesis
Actin Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Proliferation In Bone Marrow
Regulation Of Superoxide Metabolic Process
Cell-cell Adhesion
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
Co-inhibition by PD-1
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Muromonab
Teplizumab
Catumaxomab
Mosunetuzumab
Teclistamab
Odronextamab
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Lung cancer in ever smokers (
28604730
)
Pulse pressure (
27841878
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil count (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
26 interacting genes:
ADAM33
BNIP3
CD3D
CD3G
CD79B
CSK
EPS8L1
LCK
MUC15
NCK1
NCK2
NCL
PIK3R1
PKMYT1
POLR1G
PTPN22
SHC1
SNTA1
SYK
TOP2B
TRAT1
TRB
UBASH3A
UNC119
ZAP70
ZFPL1
144 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CFTR
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
Entrez ID
916
6464
HPRD ID
08923
02780
Ensembl ID
ENSG00000198851
ENSG00000160691
Uniprot IDs
P07766
P29353
PDB IDs
1A81
1SY6
1XIW
2ROL
5QU2
6JXR
7FJD
7FJE
7FJF
7PHR
8ES7
8ES8
8ES9
8F0L
8JC0
8JCB
8TW4
8TW6
8VY4
8WXE
8WY0
8WYI
8YC0
9BBC
9C3E
9CI8
9CIA
9CQ4
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
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Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
T Cell Receptor Complex
Lymphocyte Activation
Phosphotyrosine Residue Binding
Regulation Of T Cell Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Leukocyte Activation
Regulation Of Immune Response
T Cell Activation
Cell Activation
Immune Response-activating Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Adaptive Immune Response
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Lymphocyte Differentiation
Alpha-beta T Cell Receptor Complex
T Cell Selection
Negative Regulation Of T Cell Receptor Signaling Pathway
Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Mononuclear Cell Differentiation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Thymic T Cell Selection
T Cell Receptor Binding
Positive T Cell Selection
Leukocyte Differentiation
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Gamma-delta T Cell Activation
T Cell Differentiation
Thymic T Cell Selection
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Beta Selection
Immune Response
Regulation Of Cell-cell Adhesion
B Cell Activation
Positive Regulation Of Cell-cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Receptor Complex
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Plasma Membrane
Positive Regulation Of MAPK Cascade
Protein Phosphorylation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Phosphorylation
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Regulation Of Developmental Process
Protein Autophosphorylation
Immune System Process
Regulation Of Immune Response
Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Intracellular Signaling Cassette
Response To Growth Factor
Cell Activation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Cell Migration
Regulation Of Apoptotic Process
Positive Regulation Of Cell Migration
Regulation Of Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Cell Motility
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Tagcloud (Intersection)
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