FEZ2 and SAP30L

Number of citations of the paper that reports this interaction (PMID 16484223)
14

Data Source:
BioGRID (two hybrid)

		FEZ2	SAP30L
Gene Name		fasciculation and elongation protein zeta 2 (zygin II)	SAP30-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	DNA Binding Metal Ion Binding
	Biological Process	Signal Transduction Nervous System Development Axon Guidance	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Ventricular conduction ( 21076409)
Protein-Protein Interactions		18 interactors: BRD1 C16orf59 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SCOC SMC3 TBC1D25 TLK2 WWC1 ZNF251	3 interactors: FEZ1 FEZ2 HMBOX1
Entrez ID		9637	79685
HPRD ID		09213	08563
Ensembl ID		ENSG00000171055	ENSG00000164576
Uniprot IDs		Q9UHY8	Q9HAJ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Regulation Of Metabolic Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Autophagy Regulation Of Cellular Process Organelle Organization Regulation Of Autophagic Vacuole Maturation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Component Organization Mitotic Nuclear Division Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell Part Morphogenesis Establishment Of Cell Polarity Positive Regulation Of Synaptic Transmission Membrane Depolarization Peptidyl-serine Phosphorylation Cell Division Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Activation Of Phospholipase D Activity Negative Regulation Of DNA Endoreduplication Positive Regulation Of Glutamate Secretion Chromosome Organization Regulation Of Chromatin Assembly Or Disassembly Negative Regulation Of Hippo Signaling Response To Ionizing Radiation Cell Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-13 Production Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Interleukin-5 Production Positive Regulation Of T Cell Cytokine Production	Axon Guidance Axonogenesis Negative Regulation Of Macroautophagy Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Establishment Of Mitochondrion Localization Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Autophagy Mitochondrion Localization Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Regulation Of Dendrite Morphogenesis
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