FEZ2 and TBC1D25

Number of citations of the paper that reports this interaction (PMID 16484223)
14

Data Source:
BioGRID (two hybrid)

		FEZ2	TBC1D25
Gene Name		fasciculation and elongation protein zeta 2 (zygin II)	TBC1 domain family, member 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Autophagic Vacuole Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Rab GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Nervous System Development Axon Guidance	Autophagy Positive Regulation Of Rab GTPase Activity Regulation Of Autophagic Vacuole Maturation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: BRD1 C16orf59 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SCOC SMC3 TBC1D25 TLK2 WWC1 ZNF251	8 interactors: FEZ1 FEZ2 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B RAB2A
Entrez ID		9637	4943
HPRD ID		09213	08948
Ensembl ID		ENSG00000171055	ENSG00000068354
Uniprot IDs		Q9UHY8	Q3MII6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Regulation Of Metabolic Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Autophagy Regulation Of Cellular Process Organelle Organization Regulation Of Autophagic Vacuole Maturation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Component Organization Mitotic Nuclear Division Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell Part Morphogenesis Establishment Of Cell Polarity Positive Regulation Of Synaptic Transmission Membrane Depolarization Peptidyl-serine Phosphorylation Cell Division Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Activation Of Phospholipase D Activity Negative Regulation Of DNA Endoreduplication Positive Regulation Of Glutamate Secretion Chromosome Organization Regulation Of Chromatin Assembly Or Disassembly Negative Regulation Of Hippo Signaling Response To Ionizing Radiation Cell Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Interleukin-13 Production Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Interleukin-5 Production Positive Regulation Of T Cell Cytokine Production	Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Starvation Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Cellular Response To Nitrogen Starvation Mitochondrion Organization Response To Nutrient Levels Response To External Stimulus Response To Extracellular Stimulus Organelle Assembly Membrane Organization Cellular Response To Stimulus Cellular Response To Stress Catabolic Process Organelle Organization Cellular Component Assembly Response To Stimulus Cell Communication Response To Stress Establishment Of Localization In Cell Negative Regulation Of Macroautophagy Cellular Localization Establishment Of Mitochondrion Localization Axon Guidance Protein Transport Establishment Of Protein Localization Positive Regulation Of ATPase Activity Negative Regulation Of Autophagy Intracellular Transport Mitochondrion Localization Axonogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of ATPase Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis
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