PPP6R3 and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		PPP6R3	TINF2
Description		protein phosphatase 6 regulatory subunit 3	TERF1 interacting nuclear factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Regulation Of Signal Transduction	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Telomere Extension By Telomerase COPII-mediated vesicle transport	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Body size at age 10 ( 32376654) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Femoral neck section modulus ( 30888730) Fractures ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monobrow ( 27182965) QT interval ( 29213071) Serum metabolite levels ( 33031748)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		6 interacting genes: LATS1 PRKDC TERF2IP TINF2 UBC YWHAG	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		55291	26277
HPRD ID		10703	16056
Ensembl ID		ENSG00000110075	ENSG00000092330
Uniprot IDs		E9PKF6 H7BXH2 Q5H9R7	B4DFJ1 Q9BSI4
PDB IDs			3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Telomere Capping Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphate Metabolic Process Shelterin Complex Chromosome Organization Regulation Of Protein Phosphorylation Telomere Maintenance Nuclear Telomere Cap Complex Protein Localization To Chromosome Regulation Of Phosphorylation Protein Localization To Chromosome, Telomeric Region Telomere Organization Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Metabolic Process Chromosome, Telomeric Region Protein Localization To Organelle Regulation Of Protein Modification Process Telomeric DNA Binding Intracellular Protein Localization Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Kinase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Cellular Response To Insulin Stimulus Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Negative Regulation Of Metabolic Process Regulation Of Telomere Maintenance Positive Regulation Of Platelet Formation Perinucleolar Chromocenter Negative Regulation Of DNA Recombination At Telomere Regulation Of Protein Metabolic Process Protein Modification Process DNA-dependent Protein Kinase Activity Small-subunit Processome Assembly Histone H2AXS139 Kinase Activity Protein Kinase C Inhibitor Activity Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Translation Pro-B Cell Differentiation Response To Insulin T Cell Receptor V(D)J Recombination	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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