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PPP6R3 and PRKDC
Number of citations of the paper that reports this interaction (PMID
20065038
)
37
Data Source:
BioGRID
(pull down)
PPP6R3
PRKDC
Gene Name
protein phosphatase 6, regulatory subunit 3
protein kinase, DNA-activated, catalytic polypeptide
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Plasma Membrane
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Nonhomologous End Joining Complex
Molecular Function
Protein Binding
Protein Phosphatase Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Poly(A) RNA Binding
Biological Process
Regulation Of Phosphoprotein Phosphatase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Negative Regulation Of Protein Phosphorylation
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Peptidyl-serine Phosphorylation
Protein Destabilization
Positive Regulation Of Type I Interferon Production
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways
Nonhomologous End-joining (NHEJ)
Cytosolic sensors of pathogen-associated DNA
Processing of DNA ends prior to end rejoining
STING mediated induction of host immune responses
Double-Strand Break Repair
IRF3-mediated induction of type I IFN
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
LATS1
PRKDC
TERF2IP
TINF2
YWHAG
83 interactors:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CHEK1
CHEK2
CHUK
CIB1
CTDP1
DCLRE1C
E4F1
EIF2S2
EIF4EBP1
ERG
GSK3A
GSK3B
GZMB
H2AFX
HDAC3
HIST1H1A
HIST1H1C
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11A
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R2
PPP6R3
PRKCD
PTS
RAD17
RBBP8
RNF144A
RPA1
RPA2
SGOL1
SP1
SRF
THRA
THRB
TP53
TREX1
UBC
USF1
VPRBP
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
Entrez ID
55291
5591
HPRD ID
10703
02941
Ensembl ID
ENSG00000110075
ENSG00000253729
Uniprot IDs
E9PQP7
H7BXH2
Q5H9R7
P78527
PDB IDs
Enriched GO Terms of Interacting Partners
?
Telomere Maintenance
Protein Localization To Chromosome, Telomeric Region
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Organelle Organization
Protein Localization To Chromosome
Telomere Maintenance Via Telomere Lengthening
Chromosome Organization
Negative Regulation Of Protein Phosphorylation
Organelle Organization
Negative Regulation Of Phosphorylation
Cellular Protein Localization
Negative Regulation Of Chromosome Organization
Cellular Response To Hormone Stimulus
Negative Regulation Of DNA Metabolic Process
Protein Localization
Negative Regulation Of Protein ADP-ribosylation
Negative Regulation Of DNA Recombination At Telomere
Regulation Of Cellular Component Organization
Mitotic Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Protein Metabolic Process
Regulation Of Protein ADP-ribosylation
Cellular Localization
Response To Hormone
Intrinsic Apoptotic Signaling Pathway
Regulation Of Chromosome Organization
Cell Cycle Process
Negative Regulation Of Protein Glycosylation
Cellular Response To Insulin Stimulus
Negative Regulation Of Protein Kinase Activity
DNA Metabolic Process
Regulation Of Protein Phosphorylation
Negative Regulation Of Kinase Activity
Pro-B Cell Differentiation
Protection From Non-homologous End Joining At Telomere
Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomerase
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Telomere Assembly
Response To Insulin
Regulation Of Phosphorylation
Negative Regulation Of Transferase Activity
Cellular Response To Stress
DNA Repair
Cellular Response To DNA Damage Stimulus
DNA Recombination
DNA Metabolic Process
Double-strand Break Repair
Response To Stress
Immune System Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Apoptotic Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Response To Abiotic Stimulus
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Response To Organic Substance
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Immune System Development
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Cell Cycle
Cellular Response To Organic Substance
Regulation Of Nitrogen Compound Metabolic Process
Apoptotic Process
Organelle Organization
Cellular Metabolic Process
Programmed Cell Death
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cell Cycle Process
Cell Death
Death
Telomere Maintenance
Developmental Process
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter
Intrinsic Apoptotic Signaling Pathway
DNA Damage Checkpoint
Cellular Macromolecule Biosynthetic Process
Response To Stimulus
Mitotic Cell Cycle
Macromolecule Biosynthetic Process
Response To Radiation
Organ Development
Mitotic Cell Cycle Process
Tagcloud
?
1ada
1p24
antiretroviral
atazanavir
atv
boosted
capacities
carriage
coating
depots
fa
folic
il2rg
loads
mirrored
nanoart
nanocrystals
nanoformulated
p407
parafollicular
paralleled
permit
pharmacodynamic
poloxamer
reconstituted
ritonavir
szj
tm1wjl
untargeted
Tagcloud (Difference)
?
1ada
1p24
antiretroviral
atazanavir
atv
boosted
capacities
carriage
coating
depots
fa
folic
il2rg
loads
mirrored
nanoart
nanocrystals
nanoformulated
p407
parafollicular
paralleled
permit
pharmacodynamic
poloxamer
reconstituted
ritonavir
szj
tm1wjl
untargeted
Tagcloud (Intersection)
?