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LRSAM1 and GSK3A
Number of citations of the paper that reports this interaction (PMID
14635195
)
4
Data Source:
HPRD
(in vitro)
LRSAM1
GSK3A
Gene Name
leucine rich repeat and sterile alpha motif containing 1
glycogen synthase kinase 3 alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Cytoplasm
Membrane
Cytosol
Beta-catenin Destruction Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Hormone Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase A Catalytic Subunit Binding
Tau-protein Kinase Activity
Biological Process
Protein Polyubiquitination
Protein Catabolic Process
Negative Regulation Of Endocytosis
Viral Budding
Protein Autoubiquitination
Ubiquitin-dependent Endocytosis
Regulation Of Systemic Arterial Blood Pressure
Cardiac Left Ventricle Morphogenesis
Glycogen Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Protein Phosphorylation
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Epidermal Growth Factor Receptor Signaling Pathway
Nervous System Development
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of UDP-glucose Catabolic Process
Wnt Signaling Pathway
Cell Migration
Positive Regulation Of CAMP Biosynthetic Process
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of TOR Signaling
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Interleukin-3
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Hypermethylation Of CpG Island
Cellular Protein Metabolic Process
Innate Immune Response
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Heart Contraction
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Negative Regulation Of Transferase Activity
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Lithium Ion
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Adrenergic Receptor Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
Signaling by EGFRvIII in Cancer
XBP1(S) activates chaperone genes
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
IRE1alpha activates chaperones
PI3K/AKT activation
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Unfolded Protein Response (UPR)
Innate Immune System
Signaling by PDGF
DAP12 interactions
Signalling by NGF
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
36 interactors:
ATXN1
ATXN7
FAM178B
GABARAPL2
GPR108
GRIK5
GSK3A
KLC1
MDM4
MGAT4B
MKRN3
MUTYH
MYL2
NINL
PHF23
RNF111
RXRG
TERF1
TNFRSF10C
TRIM17
TRIM74
TSG101
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2H
UBE2J1
UBE2K
UBE2N
UBE2W
UEVLD
USP2
USP21
VPS11
31 interactors:
AKT1
BCL3
BICD1
CREB1
CREM
DEAF1
EBNA1BP2
EIF2B5
FAM193B
GLI3
GSKIP
HSF1
LRSAM1
MAPT
MCL1
MYC
NBR1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
PRKCH
PRKCZ
PRKD3
PRKDC
PXN
SGK1
SGK3
SPG21
YWHAG
Entrez ID
90678
2931
HPRD ID
14325
06002
Ensembl ID
ENSG00000148356
ENSG00000105723
Uniprot IDs
Q6UWE0
P49840
PDB IDs
2DFM
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Protein Metabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Toll-like Receptor Signaling Pathway
Mitotic Spindle Assembly Checkpoint
Cellular Response To Oxygen Levels
Spindle Assembly Checkpoint
Cellular Response To Stress
Mitotic Spindle Checkpoint
Regulation Of Proteolysis
Protein Monoubiquitination
Negative Regulation Of Chromosome Segregation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Activation Of Innate Immune Response
Cellular Metabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Response To Stress
Protein Phosphorylation
Regulation Of Phospholipase Activity
Apoptotic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphorylation
Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway
Platelet Activation
Cell Death
Death
Positive Regulation Of Phospholipase Activity
Cell Activation
Negative Regulation Of Cellular Metabolic Process
Regulation Of Apoptotic Process
Response To Organic Substance
Negative Regulation Of Glial Cell Apoptotic Process
Positive Regulation Of Lipase Activity
Intracellular Signal Transduction
Regulation Of Cell Death
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Histone H3-T6 Phosphorylation
Negative Regulation Of Apoptotic Process
Activation Of Phospholipase C Activity
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Metabolic Process
Apoptotic Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Phospholipase C Activity
Negative Regulation Of Cell Death
Cellular Response To Stimulus
Response To Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Phosphorylation
Regulation Of Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Body Fluid Levels
Response To Organonitrogen Compound
Developmental Process
Response To Growth Factor
Phosphate-containing Compound Metabolic Process
Wound Healing
Regulation Of Cellular Response To Insulin Stimulus
Blood Coagulation
Hemostasis
Response To Peptide Hormone
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Protein Metabolic Process
Tagcloud
?
2h
4e
accelerated
bp1
carboxymethoxyphenyl
deacetylase
dimethylthiazol
ezh2
glioma
gliomas
glycogen
incubated
mts
p70
p70s6k
pci
phosphatidylinositol
promotes
razolium
s6
simulated
sirna
sulfophenyl
suppresses
suppressing
tet
yl
zeste
Tagcloud (Difference)
?
2h
4e
accelerated
bp1
carboxymethoxyphenyl
deacetylase
dimethylthiazol
ezh2
glioma
gliomas
glycogen
incubated
mts
p70
p70s6k
pci
phosphatidylinositol
promotes
razolium
s6
simulated
sirna
sulfophenyl
suppresses
suppressing
tet
yl
zeste
Tagcloud (Intersection)
?