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LRSAM1 and MYL2
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
LRSAM1
MYL2
Gene Name
leucine rich repeat and sterile alpha motif containing 1
myosin, light chain 2, regulatory, cardiac, slow
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Cytoplasm
Membrane
Cytosol
Cytoskeleton
Actin Cytoskeleton
Myosin Complex
Myofibril
Sarcomere
A Band
Molecular Function
Ubiquitin-protein Transferase Activity
Hormone Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Actin Monomer Binding
Calcium Ion Binding
Protein Binding
Structural Constituent Of Muscle
Myosin Heavy Chain Binding
Biological Process
Protein Polyubiquitination
Protein Catabolic Process
Negative Regulation Of Endocytosis
Viral Budding
Protein Autoubiquitination
Ubiquitin-dependent Endocytosis
Regulation Of Striated Muscle Contraction
Post-embryonic Development
Muscle Filament Sliding
Negative Regulation Of Cell Growth
Muscle Cell Fate Specification
Muscle Fiber Development
Cardiac Myofibril Assembly
Ventricular Cardiac Muscle Tissue Morphogenesis
Heart Contraction
Cardiac Muscle Contraction
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Striated Muscle Contraction
Drugs
Diseases
GWAS
Alcohol consumption (
21270382
)
Coronary heart disease (
23364394
)
Drinking behavior (
23364009
)
Gamma glutamyl transpeptidase (
21909109
)
Glycemic traits (
23575436
)
HDL cholesterol (
21909109
)
Protein-Protein Interactions
36 interactors:
ATXN1
ATXN7
FAM178B
GABARAPL2
GPR108
GRIK5
GSK3A
KLC1
MDM4
MGAT4B
MKRN3
MUTYH
MYL2
NINL
PHF23
RNF111
RXRG
TERF1
TNFRSF10C
TRIM17
TRIM74
TSG101
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2H
UBE2J1
UBE2K
UBE2N
UBE2W
UEVLD
USP2
USP21
VPS11
9 interactors:
CDC42BPA
GJB5
LRSAM1
MYOC
NHP2
PAK2
PPP1R12C
TRIM63
USP6
Entrez ID
90678
4633
HPRD ID
14325
01181
Ensembl ID
ENSG00000148356
ENSG00000111245
Uniprot IDs
Q6UWE0
P10916
Q6IB42
PDB IDs
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Protein Metabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Toll-like Receptor Signaling Pathway
Mitotic Spindle Assembly Checkpoint
Cellular Response To Oxygen Levels
Spindle Assembly Checkpoint
Cellular Response To Stress
Mitotic Spindle Checkpoint
Regulation Of Proteolysis
Protein Monoubiquitination
Negative Regulation Of Chromosome Segregation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Activation Of Innate Immune Response
Cellular Metabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Skeletal Muscle Adaptation
ERBB2-ERBB3 Signaling Pathway
Skeletal Muscle Hypertrophy
RRNA Pseudouridine Synthesis
Ubiquitin-dependent Endocytosis
ERBB2 Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Spongiotrophoblast Differentiation
Cellular Protein Modification Process
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Skeletal Muscle Atrophy
Non-canonical Wnt Signaling Pathway Via MAPK Cascade
Striated Muscle Atrophy
Muscle Atrophy
Clustering Of Voltage-gated Sodium Channels
Negative Regulation Of Execution Phase Of Apoptosis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Viral Budding
Proteasomal Protein Catabolic Process
Muscle System Process
Positive Regulation Of Mitochondrial Depolarization
Negative Regulation Of Stress Fiber Assembly
Neuronal Ion Channel Clustering
Nuclear Migration
Negative Regulation Of Actin Filament Bundle Assembly
Tagcloud
?
calcium
carrier
cav1
channel
codes
computational
evidences
gla
herein
knockdown
messenger
mgp
mrfs
mscs
muscle
myh3
myogenesis
myogenic
myosin
myotube
retinol
satellite
signifies
t4
thyroxin
transportation
transthyretin
ttr
voltage
Tagcloud (Difference)
?
calcium
carrier
cav1
channel
codes
computational
evidences
gla
herein
knockdown
messenger
mgp
mrfs
mscs
muscle
myh3
myogenesis
myogenic
myosin
myotube
retinol
satellite
signifies
t4
thyroxin
transportation
transthyretin
ttr
voltage
Tagcloud (Intersection)
?