LRSAM1 and TNFRSF10C

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		LRSAM1	TNFRSF10C
Gene Name		leucine rich repeat and sterile alpha motif containing 1	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Integral Component Of Plasma Membrane Anchored Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Hormone Activity Protein Binding Zinc Ion Binding Ligase Activity	Transmembrane Signaling Receptor Activity TRAIL Binding
	Biological Process	Protein Polyubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis	Apoptotic Process Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ATXN1 ATXN7 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11	9 interactors: APOA1 FAM101B LRSAM1 RAP1A SLC27A6 SRPK1 SRPK2 TNFSF10 ZHX1
Entrez ID		90678	8794
HPRD ID		14325	04681
Ensembl ID		ENSG00000148356	ENSG00000173535
Uniprot IDs		Q6UWE0	O14798
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Mitotic Spindle Assembly Checkpoint Cellular Response To Oxygen Levels Spindle Assembly Checkpoint Cellular Response To Stress Mitotic Spindle Checkpoint Regulation Of Proteolysis Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Activation Of Innate Immune Response Cellular Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress	Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Transport Negative Regulation Of Viral Process Negative Regulation Of Cell Adhesion Molecule Production Nuclear Speck Organization Ubiquitin-dependent Endocytosis Regulation Of MRNA Processing Cell Differentiation Regulation Of RNA Splicing Negative Regulation Of Interleukin-1 Beta Secretion Developmental Process Nucleus Organization Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Negative Regulation Of Interleukin-1 Secretion Regulation Of Viral Process Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion High-density Lipoprotein Particle Clearance Platelet Activation Protein Oxidation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Cell Development Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Sperm Chromatin Condensation Viral Budding Regulation Of Intestinal Cholesterol Absorption Rap Protein Signal Transduction Phospholipid Homeostasis Peptidyl-methionine Modification Anatomical Structure Development Regulation Of Cellular Component Organization Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vasculogenesis Phospholipid Efflux Nerve Growth Factor Signaling Pathway Regulation Of Cytokine Secretion Involved In Immune Response Lipid Transport Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity
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