LRSAM1 and UEVLD

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		LRSAM1	UEVLD
Gene Name		leucine rich repeat and sterile alpha motif containing 1	UEV and lactate/malate dehyrogenase domains
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Hormone Activity Protein Binding Zinc Ion Binding Ligase Activity	Molecular_function Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Protein Polyubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis	Cellular Protein Modification Process Biological_process Protein Transport Cellular Carbohydrate Metabolic Process Oxidation-reduction Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ATXN1 ATXN7 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11	6 interactors: DTX3 LRSAM1 RNF114 RNF4 TRAF6 UBC
Entrez ID		90678	55293
HPRD ID		14325	15608
Ensembl ID		ENSG00000148356	ENSG00000151116
Uniprot IDs		Q6UWE0	B4DIA9 Q8IX04
PDB IDs			2I6T 3DL2
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Mitotic Spindle Assembly Checkpoint Cellular Response To Oxygen Levels Spindle Assembly Checkpoint Cellular Response To Stress Mitotic Spindle Checkpoint Regulation Of Proteolysis Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Activation Of Innate Immune Response Cellular Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Autoubiquitination Cellular Protein Modification Process Intracellular Receptor Signaling Pathway Virion Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway JNK Cascade Ubiquitin-dependent Endocytosis Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Protein Catabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Regulation Of Kinetochore Assembly Antigen Receptor-mediated Signaling Pathway Notch Signaling Pathway Activation Of MAPK Activity Activation Of Innate Immune Response Regulation Of Centromere Complex Assembly Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway
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