LRSAM1 and UEVLD

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		LRSAM1	UEVLD
Description		leucine rich repeat and sterile alpha motif containing 1	UEV and lactate/malate dehyrogenase domains
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	ESCRT I Complex Cytoplasm Vesicle Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Catalytic Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Ubiquitin Binding
	Biological Process	Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Endosome To Lysosome Transport Protein Transport Carboxylic Acid Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)
Interacting Genes		46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4	6 interacting genes: DTX3 LRSAM1 RNF114 RNF4 TRAF6 UBC
Entrez ID		90678	55293
HPRD ID		14325	15608
Ensembl ID		ENSG00000148356	ENSG00000151116
Uniprot IDs		A0A6Q8PGW1 Q6UWE0	B4DIA9 Q8IX04
PDB IDs			2I6T 3DL2
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Autoubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Transferase Activity Zinc Ion Binding Macromolecule Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Kinetochore Assembly Modification-dependent Protein Catabolic Process Positive Regulation Of Synoviocyte Proliferation Regulation Of Centromere Complex Assembly SUMO Polymer Binding Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Localization To Chromatin Microtubule End Interleukin-17A-mediated Signaling Pathway Ubiquitin-dependent Endocytosis Macromolecule Metabolic Process
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