LRSAM1 and PHF23

Number of citations of the paper that reports this interaction (PubMedID 25484098)
39

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (two hybrid)

		LRSAM1	PHF23
Description		leucine rich repeat and sterile alpha motif containing 1	PHD finger protein 23
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Autophagy Positive Regulation Of Protein Ubiquitination Negative Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4	6 interacting genes: ERBB2 LRSAM1 PRSS23 STK11 TRIM55 TRIM63
Entrez ID		90678	79142
HPRD ID		14325	08325
Ensembl ID		ENSG00000148356	ENSG00000040633
Uniprot IDs		A0A6Q8PGW1 Q6UWE0	I3L1N0 Q9BUL5
PDB IDs			6WXK
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process	Protein Modification Process Transferase Activity Protein Metabolic Process Ubiquitin Protein Ligase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Protein Localization To Organelle Negative Regulation Of Immature T Cell Proliferation Regulation Of Phosphorus Metabolic Process ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus Macromolecule Metabolic Process ERBB2-ERBB4 Signaling Pathway Immune System Process LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Positive Regulation Of Autophagy Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Ubiquitin-dependent Endocytosis Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation ERBB2-ERBB3 Signaling Pathway Regulation Of Kinase Activity ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Organelle Transport Along Microtubule Epithelial Cell Proliferation Involved In Prostate Gland Development Diapedesis Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Ubiquitin-protein Transferase Activity Positive Regulation Of Xenophagy Regulation Of Microtubule-based Process Negative Regulation Of T Cell Differentiation In Thymus Dendrite Extension Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Semaphorin Receptor Complex Positive Regulation Of Phosphate Metabolic Process
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