GSK3A and FAM193B

Number of citations of the paper that reports this interaction (PubMedID 20368287)
102

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		GSK3A	FAM193B
Description		glycogen synthase kinase 3 alpha	family with sequence similarity 193 member B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Nervous System Development Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Viral Protein Processing Cell Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lithium Ion Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Autosome Genomic Imprinting Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitophagy Cellular Response To Oxygen-containing Compound Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity
Pathways		AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		Fostamatinib
Diseases
GWAS		Meat-related diet ( 32066663)	Appendicular lean mass ( 33097823) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		76 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B GLI3 GOLGA6C H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LCOR LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG	12 interacting genes: ATXN1 CDC25A CNOT11 GOLGA2 GSK3A GSK3B LDOC1 MAPK8 PKN2 SPANXN2 TRIM23 TRIM27
Entrez ID		2931	54540
HPRD ID		06002	07671
Ensembl ID		ENSG00000105723	ENSG00000146067
Uniprot IDs		P49840	Q96PV7
PDB IDs		7SXF 7SXG
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Peptide Hormone Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Response To Heat Regulation Of Apoptotic Process Response To Hormone Macromolecule Metabolic Process Nucleoplasm Protein Phosphorylation Protein Serine Kinase Activity Nucleus Cytoplasmic Translation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Heat Phosphorylation Protein Serine/threonine Kinase Activity Cellular Response To Stress Protein Kinase C Signaling Response To Temperature Stimulus Positive Regulation Of Immune System Process Cytoplasm Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Response To Stress Intracellular Signal Transduction Protein Kinase Activity Leukocyte Apoptotic Process Positive Regulation Of Leukocyte Differentiation Translation Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Positive Regulation Of Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Translation Cellular Response To Oxygen-containing Compound Protein Serine/threonine/tyrosine Kinase Activity CAMP/PKA Signal Transduction DNA Damage Response Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Localization Nucleic Acid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Metabolic Process Kinase Activity	Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Protein Binding Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Autophagy Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cellular Response To Interleukin-3 Excitatory Postsynaptic Potential Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Beta-catenin Destruction Complex Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding Protein Serine Kinase Activity Tau-protein Kinase Activity Negative Regulation Of Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Protein Binding Regulation Of Glycogen Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Membrane Permeability Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Glycogen Metabolic Process Protein Modification Process Tau Protein Binding Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Postsynapse Transferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Kinase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Microtubule Anchoring At Centrosome JUN Phosphorylation Regulation Of Protein Modification Process Glycogen Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Membrane Permeability Positive Regulation Of Neuron Apoptotic Process
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