LRSAM1 and ATXN7

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		LRSAM1	ATXN7
Description		leucine rich repeat and sterile alpha motif containing 1	ataxin 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	SAGA Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton Nuclear Matrix Transcription Factor TFTC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Microtubule Cytoskeleton Organization Regulation Of DNA Repair Regulation Of Transcription By RNA Polymerase II Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Mean corpuscular volume ( 32888494)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)
Interacting Genes		46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4	58 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		90678	6314
HPRD ID		14325	06365
Ensembl ID		ENSG00000148356	ENSG00000163635
Uniprot IDs		A0A6Q8PGW1 Q6UWE0	O15265 Q9UPD8
PDB IDs			2KKR 7KTR 7KTS 8H7G
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process	Extracellular Matrix Structural Constituent Integrin Binding Basement Membrane Identical Protein Binding Calcium Ion Binding Platelet Alpha Granule Lumen Extracellular Matrix Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Extracellular Region Cell-substrate Junction Assembly Microfibril Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cell-substrate Junction Organization Pseudopodium Positive Regulation Of Protein Metabolic Process Transcription Factor TFTC Complex Positive Regulation Of Metabolic Process Ubiquitin-specific Protease Binding Cytoplasm Regulation Of Protein Catabolic Process Laminin Complex SAGA Complex Actin Filament Binding Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Focal Adhesion Assembly Regulation Of Cellular Component Organization Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Protein Binding Positive Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Nervous System Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Post-embryonic Eye Morphogenesis Heparin Binding Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Basement Membrane Organization Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Xenophagy Protein Complex Involved In Cell-matrix Adhesion
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