GSK3A and SGK3

Number of citations of the paper that reports this interaction (PMID 11035810)
124

Data Source:
HPRD (in vivo, in vitro)

		GSK3A	SGK3
Gene Name		glycogen synthase kinase 3 alpha	serum/glucocorticoid regulated kinase family, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Beta-catenin Destruction Complex	Early Endosome Cytosol Cytoplasmic Membrane-bounded Vesicle Recycling Endosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase A Catalytic Subunit Binding Tau-protein Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Phosphatidylinositol Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of UDP-glucose Catabolic Process Wnt Signaling Pathway Cell Migration Positive Regulation Of CAMP Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of TOR Signaling Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interleukin-3 Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Hypermethylation Of CpG Island Cellular Protein Metabolic Process Innate Immune Response Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Transferase Activity Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Cell Growth Protein Phosphorylation Response To Stress Regulation Of Cell Migration Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer XBP1(S) activates chaperone genes Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) IRE1alpha activates chaperones PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Unfolded Protein Response (UPR) Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKT1 BCL3 BICD1 CREB1 CREM DEAF1 EBNA1BP2 EIF2B5 FAM193B GLI3 GSKIP HSF1 LRSAM1 MAPT MCL1 MYC NBR1 PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PXN SGK1 SGK3 SPG21 YWHAG	6 interactors: APP GSK3A GSK3B ITCH PDPK1 SLC9A3R2
Entrez ID		2931	23678
HPRD ID		06002	06349
Ensembl ID		ENSG00000105723	ENSG00000104205
Uniprot IDs		P49840	Q53EW6 Q5H9Q5 Q96BR1
PDB IDs		2DFM
Enriched GO Terms of Interacting Partners?		Response To Stress Protein Phosphorylation Regulation Of Phospholipase Activity Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphorylation Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Platelet Activation Cell Death Death Positive Regulation Of Phospholipase Activity Cell Activation Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Intracellular Signal Transduction Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Apoptotic Process Activation Of Phospholipase C Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Negative Regulation Of Cell Death Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Phosphorylation Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Organonitrogen Compound Developmental Process Response To Growth Factor Phosphate-containing Compound Metabolic Process Wound Healing Regulation Of Cellular Response To Insulin Stimulus Blood Coagulation Hemostasis Response To Peptide Hormone Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process	Negative Regulation Of Type B Pancreatic Cell Development Hypermethylation Of CpG Island Innate Immune Response Cellular Response To Interleukin-3 Apoptotic Process Programmed Cell Death Negative Regulation Of Glycogen (starch) Synthase Activity Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Locomotion Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Regulation Of Signal Transduction Immune Response Regulation Of Phosphorylation Defense Response Phosphatidylinositol-mediated Signaling Regulation Of Signaling Regulation Of Type B Pancreatic Cell Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Growth Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of DNA Methylation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Neurotrophin Signaling Pathway Negative Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Response To Lithium Ion Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts p70 p70s6k pci phosphatidylinositol promotes razolium s6 simulated sirna sulfophenyl suppresses suppressing tet yl zeste	androgen ar confers depletion dht eralpha erbeta functionally functioning g1 glucocorticoid identifies inducible inhibiting isoforms lncap locus p70 p70s6k phosphatidylinositol pi3k promoters promotes prostate responsiveness s6 ser summary thr
Tagcloud (Difference) ?		2h 4e accelerated bp1 carboxymethoxyphenyl deacetylase dimethylthiazol ezh2 glioma gliomas glycogen incubated mts pci razolium simulated sirna sulfophenyl suppresses suppressing tet yl zeste	androgen ar confers depletion dht eralpha erbeta functionally functioning g1 glucocorticoid identifies inducible inhibiting isoforms lncap locus pi3k promoters prostate responsiveness ser summary thr
Tagcloud (Intersection) ?		p70 p70s6k phosphatidylinositol promotes s6