GSK3A and MAEA

Number of citations of the paper that reports this interaction (PubMedID 30824926)
69

Data Source:
BioGRID (two hybrid)

		GSK3A	MAEA
Description		glycogen synthase kinase 3 alpha	macrophage erythroblast attacher, E3 ubiquitin ligase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Nuclear Matrix GID Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Actin Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Nervous System Development Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Viral Protein Processing Cell Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lithium Ion Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Autosome Genomic Imprinting Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitophagy Cellular Response To Oxygen-containing Compound Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity	Cytoskeleton Organization Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Erythrocyte Development Enucleate Erythrocyte Development Cell Division
Pathways		AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein	Regulation of pyruvate metabolism
Drugs		Fostamatinib	Tetrachlorodecaoxide
Diseases
GWAS		Meat-related diet ( 32066663)	Fasting glucose ( 34059833) Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 22158537 23945395 26818947 28869590 30297969 30718926 32499647)
Interacting Genes		76 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B GLI3 GOLGA6C H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LCOR LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG	6 interacting genes: GID4 GSK3A MYOC UBE2D3 UBE2H UBE2R2
Entrez ID		2931	10296
HPRD ID		06002	08427
Ensembl ID		ENSG00000105723	ENSG00000090316
Uniprot IDs		P49840	B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9
PDB IDs		7SXF 7SXG	8PJN
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Peptide Hormone Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Response To Heat Regulation Of Apoptotic Process Response To Hormone Macromolecule Metabolic Process Nucleoplasm Protein Phosphorylation Protein Serine Kinase Activity Nucleus Cytoplasmic Translation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Heat Phosphorylation Protein Serine/threonine Kinase Activity Cellular Response To Stress Protein Kinase C Signaling Response To Temperature Stimulus Positive Regulation Of Immune System Process Cytoplasm Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Response To Stress Intracellular Signal Transduction Protein Kinase Activity Leukocyte Apoptotic Process Positive Regulation Of Leukocyte Differentiation Translation Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Positive Regulation Of Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Translation Cellular Response To Oxygen-containing Compound Protein Serine/threonine/tyrosine Kinase Activity CAMP/PKA Signal Transduction DNA Damage Response Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Localization Nucleic Acid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Metabolic Process Kinase Activity	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Proteasomal Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin-protein Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Polyubiquitination Protein K11-linked Ubiquitination Catabolic Process Regulation Of Protein Targeting To Mitochondrion Protein Monoubiquitination Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of UDP-glucose Catabolic Process Skeletal Muscle Hypertrophy ATP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Nucleotide Binding Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Clustering Of Voltage-gated Sodium Channels Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Myosin Light Chain Binding Skeletal Muscle Adaptation Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Wnt Signaling Pathway
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