GSK3A and EBNA1BP2

Number of citations of the paper that reports this interaction (PubMedID 21220517)
55

Data Source:
BioGRID (enzymatic study)

		GSK3A	EBNA1BP2
Description		glycogen synthase kinase 3 alpha	EBNA1 binding protein 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite	Nucleus Chromosome Nucleolus Preribosome, Large Subunit Precursor Nuclear Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	RNA Binding Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Nervous System Development Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Viral Protein Processing Cell Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lithium Ion Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Autosome Genomic Imprinting Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitophagy Cellular Response To Oxygen-containing Compound Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity	RRNA Processing Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Fostamatinib
Diseases
GWAS		Meat-related diet ( 32066663)	Metabolite levels ( 23823483)
Interacting Genes		76 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B GLI3 GOLGA6C H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LCOR LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG	5 interacting genes: CEP70 FAM9B FBXW7 FGF3 GSK3A
Entrez ID		2931	10969
HPRD ID		06002	16849
Ensembl ID		ENSG00000105723	ENSG00000117395
Uniprot IDs		P49840	H7C2Q8 Q6IB29 Q99848
PDB IDs		7SXF 7SXG	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Peptide Hormone Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Response To Heat Regulation Of Apoptotic Process Response To Hormone Macromolecule Metabolic Process Nucleoplasm Protein Phosphorylation Protein Serine Kinase Activity Nucleus Cytoplasmic Translation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Heat Phosphorylation Protein Serine/threonine Kinase Activity Cellular Response To Stress Protein Kinase C Signaling Response To Temperature Stimulus Positive Regulation Of Immune System Process Cytoplasm Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Response To Stress Intracellular Signal Transduction Protein Kinase Activity Leukocyte Apoptotic Process Positive Regulation Of Leukocyte Differentiation Translation Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Positive Regulation Of Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Translation Cellular Response To Oxygen-containing Compound Protein Serine/threonine/tyrosine Kinase Activity CAMP/PKA Signal Transduction DNA Damage Response Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Localization Nucleic Acid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Metabolic Process Kinase Activity	Regulation Of Proteasomal Protein Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Mitochondrion Organization Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cardiac Muscle Tissue Development Response To Symbiotic Bacterium Response To UV Response To Symbiont Negative Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Phospholipid-hydroperoxide Glutathione Peroxidase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Glycogen (starch) Synthase Activity Ubiquitin Recycling Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Osteoclast Development Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Macroautophagy Lewy Body Positive Regulation Of Proteolysis Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
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