LRSAM1 and TRIM17

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		LRSAM1	TRIM17
Description		leucine rich repeat and sterile alpha motif containing 1	tripartite motif containing 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cytoplasm Lysosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Protein Localization Innate Immune Response Protein Autoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)
Interacting Genes		46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4	20 interacting genes: BAX HGS LGALS3 LGALS8 LRSAM1 MEOX2 MNAT1 TRAF6 TRIM39 TRIM41 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2N UBE2W USP15
Entrez ID		90678	51127
HPRD ID		14325	05839
Ensembl ID		ENSG00000148356	ENSG00000162931
Uniprot IDs		A0A6Q8PGW1 Q6UWE0	B3KP04 Q9Y577
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Catabolic Process Protein Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Protein Autoubiquitination Negative Regulation Of Signaling Negative Regulation Of Cell Communication Macromolecule Metabolic Process Response To Virus Cytosol Nucleus DNA Damage Response Response To Other Organism Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Response To External Biotic Stimulus Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination ATP Binding Positive Regulation Of Immune System Process Antiviral Innate Immune Response TOR Signaling Defense Response To Symbiont Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Defense Response To Other Organism Proteasomal Protein Catabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Defense Response To Virus Negative Regulation Of Cellular Response To Growth Factor Stimulus
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