LRSAM1 and MDM4

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		LRSAM1	MDM4
Gene Name		leucine rich repeat and sterile alpha motif containing 1	MDM4, p53 regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Hormone Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Protein Polyubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process G0 To G1 Transition Protein Stabilization Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Breast cancer ( 23535733) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Prostate cancer ( 23535732)
Protein-Protein Interactions		36 interactors: ATXN1 ATXN7 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11	42 interactors: AKT1 APP ARF1 ATM CAPN7 CASP3 CD160 CDK1 CHEK1 CHEK2 CSNK1A1 E2F1 EP300 LRSAM1 MDM2 MKRN3 MNAT1 PRKAA1 RAD54B RB1 RN5S1@ RNF115 SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		90678	4194
HPRD ID		14325	04082
Ensembl ID		ENSG00000148356	ENSG00000198625
Uniprot IDs		Q6UWE0	O15151 Q59FS6 Q68DC0
PDB IDs			2CR8 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3U15
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Mitotic Spindle Assembly Checkpoint Cellular Response To Oxygen Levels Spindle Assembly Checkpoint Cellular Response To Stress Mitotic Spindle Checkpoint Regulation Of Proteolysis Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Activation Of Innate Immune Response Cellular Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Response To Abiotic Stimulus Cellular Response To Stress Cell Cycle Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Hypoxia Positive Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Response To Oxygen Levels Response To Stress Regulation Of Cell Death Cellular Response To Stimulus Regulation Of Intracellular Transport Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Signal Transduction Regulation Of Cellular Component Organization Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction
Tagcloud ?			aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Difference) ?			aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Intersection) ?