GSK3A and SGK1

Number of citations of the paper that reports this interaction (PubMedID 16543730)
0

Data Source:
HPRD (in vitro, in vivo)

		GSK3A	SGK1
Description		glycogen synthase kinase 3 alpha	serum/glucocorticoid regulated kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Nervous System Development Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Viral Protein Processing Cell Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lithium Ion Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Autosome Genomic Imprinting Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitophagy Cellular Response To Oxygen-containing Compound Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone
Pathways		AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein	PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs		Fostamatinib	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Meat-related diet ( 32066663)	Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		76 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B GLI3 GOLGA6C H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LCOR LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG	38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC
Entrez ID		2931	6446
HPRD ID		06002	04264
Ensembl ID		ENSG00000105723	ENSG00000118515
Uniprot IDs		P49840	B7Z325 E9PR89 O00141
PDB IDs		7SXF 7SXG	2R5T 3HDM 3HDN 7PUE
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Peptide Hormone Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Response To Heat Regulation Of Apoptotic Process Response To Hormone Macromolecule Metabolic Process Nucleoplasm Protein Phosphorylation Protein Serine Kinase Activity Nucleus Cytoplasmic Translation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Cellular Response To Heat Phosphorylation Protein Serine/threonine Kinase Activity Cellular Response To Stress Protein Kinase C Signaling Response To Temperature Stimulus Positive Regulation Of Immune System Process Cytoplasm Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Response To Stress Intracellular Signal Transduction Protein Kinase Activity Leukocyte Apoptotic Process Positive Regulation Of Leukocyte Differentiation Translation Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Positive Regulation Of Metabolic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Translation Cellular Response To Oxygen-containing Compound Protein Serine/threonine/tyrosine Kinase Activity CAMP/PKA Signal Transduction DNA Damage Response Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Protein Localization Nucleic Acid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Metabolic Process Kinase Activity	Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus
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