LRSAM1 and UBE2E1

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		LRSAM1	UBE2E1
Gene Name		leucine rich repeat and sterile alpha motif containing 1	ubiquitin-conjugating enzyme E2E 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Hormone Activity Protein Binding Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis	Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Histone Monoubiquitination Protein Ubiquitination Cytokine-mediated Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation ISG15 antiviral mechanism Interferon Signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Cytokine Signaling in Immune system APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Antiviral mechanism by IFN-stimulated genes APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ATXN1 ATXN7 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11	100 interactors: ARIH2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PARK2 PBX2 POLL POLM RELA RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF25 RNF26 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM23 TRIM27 TRIM28 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM7 UBA1 UBASH3B UBE2G1 UBE3A UBOX5 UFM1 USP7 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		90678	7324
HPRD ID		14325	04225
Ensembl ID		ENSG00000148356	ENSG00000170142
Uniprot IDs		Q6UWE0	B7Z306 P51965
PDB IDs			1XR9 3BZH 4JJQ
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Mitotic Spindle Assembly Checkpoint Cellular Response To Oxygen Levels Spindle Assembly Checkpoint Cellular Response To Stress Mitotic Spindle Checkpoint Regulation Of Proteolysis Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Activation Of Innate Immune Response Cellular Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Monoubiquitination Proteolysis Catabolic Process Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Histone H2A Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Histone H2A Monoubiquitination Response To Misfolded Protein Regulation Of Signal Transduction Histone Modification Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Cellular Process Positive Regulation Of Protein Catabolic Process
Tagcloud ?			array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?			array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?